Propanoic acid, 2-(4-phenoxyphenoxy)-, methyl ester

Base Information

• Chemical Name: Propanoic acid, 2-(4-phenoxyphenoxy)-, methyl ester
• CAS No.: 153472-86-7
• Molecular Formula: C₁₆H₁₆O₄
• Molecular Weight: 272.301
• Mol file: 153472-86-7.mol

Synonyms:Propanoicacid, 2-(4-phenoxyphenoxy)-, methyl ester, (?à)-

Chemical Property of Propanoic acid, 2-(4-phenoxyphenoxy)-, methyl ester

Chemical Property:

• Vapor Pressure: 1.06E-05mmHg at 25°C
• Boiling Point: 371.1°C at 760 mmHg
• Flash Point: 162.2°C
• PSA: 44.76000
• Density: 1.147g/cm³
• LogP: 3.41920

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 2-(4-phenoxyphenoxy)-, methyl ester

There total 5 articles about Propanoic acid, 2-(4-phenoxyphenoxy)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 2-bromopropionate (5445-17-0) + 4-Phenoxyphenol (831-82-3) → methyl 2-(4-phenoxyphenoxy)propanoate (153472-86-7,55846-00-9)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1016/j.bioorg.2022.105695

Reference yield:

(S)-Methyl lactate (27871-49-4,2155-30-8) + 4-Phenoxyphenol (831-82-3) → (S)-methyl 2-(4-phenoxyphenoxy)propanoate (153545-81-4,153472-86-7,55846-00-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 18h;

DOI:10.1021/ja2095975

Reference yield:

(R)-Methyl lactate (17392-83-5,2155-30-8) + 4-Phenoxyphenol (831-82-3) → (R)-methyl 2-(4-phenoxyphenoxy)propanoate (153472-86-7,55846-00-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 18h;

DOI:10.1021/ja2095975

upstream raw materials:

Methyl 2-bromopropionate

Potassium; 4-phenoxy-phenolate

4-Phenoxyphenol

methyl (2S)-2-bromopropanoate

Downstream raw materials:

2-(4-phenoxy-phenoxy)-propionic acid

Refernces

• 1、 Tobisu, Mamoru,Kinuta, Hirotaka,Kita, Yusuke,Remond, Emmanuelle,Chatani, Naoto. "Rhodium(I)-catalyzed borylation of nitriles through the cleavage of carbon-cyano bonds". supporting information; experimental part. p. 115 - 118. Retrieved 2012/03/07.