(S)-PIPERIDIN-3-YL-ACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: (S)-PIPERIDIN-3-YL-ACETIC ACID ETHYL ESTER
• CAS No.: 188883-58-1
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.239
• Hs Code.: 2933399090
• Mol file: 188883-58-1.mol

Synonyms:

Chemical Property of (S)-PIPERIDIN-3-YL-ACETIC ACID ETHYL ESTER

Chemical Property:

• PSA: 38.33000
• LogP: 2.07000
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-Ethyl2-(Piperidin-3-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-Ethyl 2-(Piperidin-3-yl)acetate is used as a reagent in the synthesis of phenylethylaminopyrimidinylpiperidine derivatives which can be used as prostaglandin D2 receptor antagonists.

Technology Process of (S)-PIPERIDIN-3-YL-ACETIC ACID ETHYL ESTER

There total 6 articles about (S)-PIPERIDIN-3-YL-ACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 2-(piperidin-3-yl)acetate (64995-88-6,81290-45-1) → ethyl (S)-2-(piperidin-3-yl)acetate (188883-58-1)

Guidance literature:

With (R)-Mandelic Acid; In ethyl acetate; for 4h; optical yield given as %ee; Reflux; Resolution of racemate;

DOI:10.1080/00397911.2010.536293

Reference yield:

ethyl (S)-2-(piperidin-3-yl)acetate (D)-mandelate (193629-24-2) → ethyl (S)-2-(piperidin-3-yl)acetate (188883-58-1)

Guidance literature:

With potassium carbonate; In ethyl acetate;

Reference yield:

pyridin-3-yl-acetic acid ethyl ester (39931-77-6) → ethyl (S)-2-(piperidin-3-yl)acetate (188883-58-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen; L-Tartaric acid; Adam’s catalyst / ethanol / 5 h / 20 °C / 2585.81 Torr

1.2: pH 11 - 12

2.1: ethyl acetate

3.1: potassium carbonate / ethyl acetate

With Adam’s catalyst; L-Tartaric acid; hydrogen; potassium carbonate; In ethanol; ethyl acetate;

upstream raw materials:

pyridin-3-yl-acetic acid ethyl ester

ethyl 2-(piperidin-3-yl)acetate

ethyl (S)-2-(piperidin-3-yl)acetate (D)-mandelate

1-benzyl-3-ethoxycarbonylmethyl-pyridinium chloride

Downstream raw materials:

C₂₃H₂₉F₃N₄O₄

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