L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, (3R)-1-[(1S)-1-[[(1R)-1-carboxy-2-phenylethoxy]carbonyl]-3-methylbutyl] -2-oxo-3-pyrrolidinyl ester

Base Information

Chemical Name:L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, (3R)-1-[(1S)-1-[[(1R)-1-carboxy-2-phenylethoxy]carbonyl]-3-methylbutyl] -2-oxo-3-pyrrolidinyl ester
CAS No.:188908-76-1
Molecular Formula:C31H46N2O9
Molecular Weight:590.714
Hs Code.:

L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-,
(3R)-1-[(1S)-1-[[(1R)-1-carboxy-2-phenylethoxy]carbonyl]-3-methylbutyl]
-2-oxo-3-pyrrolidinyl ester

Synonyms:

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Chemical Property of L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, (3R)-1-[(1S)-1-[[(1R)-1-carboxy-2-phenylethoxy]carbonyl]-3-methylbutyl] -2-oxo-3-pyrrolidinyl ester

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Technology Process of L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, (3R)-1-[(1S)-1-[[(1R)-1-carboxy-2-phenylethoxy]carbonyl]-3-methylbutyl] -2-oxo-3-pyrrolidinyl ester

There total 5 articles about L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-, (3R)-1-[(1S)-1-[[(1R)-1-carboxy-2-phenylethoxy]carbonyl]-3-methylbutyl] -2-oxo-3-pyrrolidinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 188908-75-0
(S)-2-{(R)-3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoyloxy]-2-oxo-pyrrolidin-1-yl}-4-methyl-pentanoic acid (R)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

: 188908-76-1
(S)-2-{(R)-3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoyloxy]-2-oxo-pyrrolidin-1-yl}-4-methyl-pentanoic acid (R)-1-carboxy-2-phenyl-ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2327.17 - 2585.74 Torr;
DOI:10.1021/jm020482k

Reference yield:

: 53363-89-6
N-t-butoxycarbonyl-N-methyl-L-leucine

: 188908-76-1
(S)-2-{(R)-3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoyloxy]-2-oxo-pyrrolidin-1-yl}-4-methyl-pentanoic acid (R)-1-carboxy-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

2: 98 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

3: 87 percent / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

4: 95 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm020482k

Reference yield:

: 188908-64-7
benzyl (2S)-2-[(3R)-3-hydroxy-2-oxopyrrolidinyl]-4-methylpentanoate

: 188908-76-1
(S)-2-{(R)-3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoyloxy]-2-oxo-pyrrolidin-1-yl}-4-methyl-pentanoic acid (R)-1-carboxy-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

2: 98 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

3: 87 percent / DCC; DMAP / CH₂Cl₂ / 3 h / 25 °C

4: 95 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm020482k