N-(5-Methoxy-5-oxopentyl)-L-leucine phenylmethyl ester

Base Information

Chemical Name:N-(5-Methoxy-5-oxopentyl)-L-leucine phenylmethyl ester
CAS No.:188908-90-9
Molecular Formula:C19H29NO4
Molecular Weight:335.444
Hs Code.:
DSSTox Substance ID:DTXSID301210324

Synonyms:DTXSID301210324;N-(5-Methoxy-5-oxopentyl)-L-leucine phenylmethyl ester;188908-90-9

Suppliers and Price of N-(5-Methoxy-5-oxopentyl)-L-leucine phenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-Methoxy-5-oxopentyl)-L-leucine phenylmethyl ester

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:13
Exact Mass:335.20965841
Heavy Atom Count:24
Complexity:364

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)CC(C(=O)OCC1=CC=CC=C1)NCCCCC(=O)OC
Isomeric SMILES:CC(C)C[C@@H](C(=O)OCC1=CC=CC=C1)NCCCCC(=O)OC

Technology Process of N-(5-Methoxy-5-oxopentyl)-L-leucine phenylmethyl ester

There total 4 articles about N-(5-Methoxy-5-oxopentyl)-L-leucine phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 5454-83-1
5-bromovaleric acid methyl ester

: 1738-69-8
L-Leucine benzyl ester

: 188908-90-9
methyl 5-[N-((1S)-1-benzyloxycarbonyl-3-methylbutyl)amino]pentanoate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 130 ℃; for 1.5h;
DOI:10.1021/jm020482k

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 188908-90-9
methyl 5-[N-((1S)-1-benzyloxycarbonyl-3-methylbutyl)amino]pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium carbonate / dimethylformamide / 0 °C

1.2: 95 percent / dimethylformamide / 0 - 25 °C

2.1: 100 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

3.1: 91 percent / NaHCO₃ / dimethylformamide / 1.5 h / 130 °C

With sodium hydrogencarbonate; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020482k

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 188908-90-9
methyl 5-[N-((1S)-1-benzyloxycarbonyl-3-methylbutyl)amino]pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / aq. NaOH / dioxane / 23 h / 25 °C

2.1: cesium carbonate / dimethylformamide / 0 °C

2.2: 95 percent / dimethylformamide / 0 - 25 °C

3.1: 100 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

4.1: 91 percent / NaHCO₃ / dimethylformamide / 1.5 h / 130 °C

With sodium hydroxide; sodium hydrogencarbonate; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020482k