4H-1-Benzopyran-4-one, 2-[3,4-bis(phenylmethoxy)phenyl]-6-methoxy-5-(1-methylethoxy)-7-(phen ylmethoxy)-

Base Information

• Chemical Name: 4H-1-Benzopyran-4-one, 2-[3,4-bis(phenylmethoxy)phenyl]-6-methoxy-5-(1-methylethoxy)-7-(phen ylmethoxy)-
• CAS No.: 188927-51-7
• Molecular Formula: C40H36O7
• Molecular Weight: 628.722
• Mol file: 188927-51-7.mol

Synonyms:

Chemical Property of 4H-1-Benzopyran-4-one, 2-[3,4-bis(phenylmethoxy)phenyl]-6-methoxy-5-(1-methylethoxy)-7-(phen ylmethoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4H-1-Benzopyran-4-one, 2-[3,4-bis(phenylmethoxy)phenyl]-6-methoxy-5-(1-methylethoxy)-7-(phen ylmethoxy)-

There total 8 articles about 4H-1-Benzopyran-4-one, 2-[3,4-bis(phenylmethoxy)phenyl]-6-methoxy-5-(1-methylethoxy)-7-(phen ylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(4-Benzyloxy-6-hydroxy-2-isopropoxy-3-methoxy-phenyl)-3-(3,4-bis-benzyloxy-phenyl)-propane-1,3-dione (188927-36-8) → 7-Benzyloxy-2-(3,4-bis-benzyloxy-phenyl)-5-isopropoxy-6-methoxy-chromen-4-one (188927-51-7)

Guidance literature:

With sulfuric acid; acetic acid; at 50 ℃; for 1h;

DOI:10.1248/cpb.45.446

Reference yield:

1-(2,4-Bis-benzyloxy-3,6-dimethoxy-phenyl)-ethanone (3162-51-4) → 7-Benzyloxy-2-(3,4-bis-benzyloxy-phenyl)-5-isopropoxy-6-methoxy-chromen-4-one (188927-51-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / conc. HCl, acetic acid / 1 h / Ambient temperature

2: 83 percent / K₂CO₃, KI / acetone; dimethylformamide / Heating

3: 75 percent / AlBr₃, NaI / acetonitrile / 0.25 h / 0 °C

4: pyridine / 2 h / 70 - 80 °C

5: KOH / pyridine / 80 °C

6: 97 percent / conc. H₂SO₄, acetic acid / 1 h / 50 °C

With pyridine; hydrogenchloride; potassium hydroxide; aluminum tri-bromide; sulfuric acid; potassium carbonate; acetic acid; potassium iodide; sodium iodide; In pyridine; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1248/cpb.45.446

Reference yield:

1-(4-benzyloxy-2-hydroxy-3,6-dimethoxy-phenyl)-ethanone (3162-52-5) → 7-Benzyloxy-2-(3,4-bis-benzyloxy-phenyl)-5-isopropoxy-6-methoxy-chromen-4-one (188927-51-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / K₂CO₃, KI / acetone; dimethylformamide / Heating

2: 75 percent / AlBr₃, NaI / acetonitrile / 0.25 h / 0 °C

3: pyridine / 2 h / 70 - 80 °C

4: KOH / pyridine / 80 °C

5: 97 percent / conc. H₂SO₄, acetic acid / 1 h / 50 °C

With pyridine; potassium hydroxide; aluminum tri-bromide; sulfuric acid; potassium carbonate; acetic acid; potassium iodide; sodium iodide; In pyridine; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1248/cpb.45.446

upstream raw materials:

1-(4-Benzyloxy-6-hydroxy-2-isopropoxy-3-methoxy-phenyl)-3-(3,4-bis-benzyloxy-phenyl)-propane-1,3-dione

1-(2,4-Bis-benzyloxy-3,6-dimethoxy-phenyl)-ethanone

1-(4-benzyloxy-2-hydroxy-3,6-dimethoxy-phenyl)-ethanone

1-(2,4-dihydroxy-3,6-dimethoxy)phenylethanone

Downstream raw materials:

7-Benzyloxy-2-(3,4-bis-benzyloxy-phenyl)-3-hydroxy-5-isopropoxy-6-methoxy-chromen-4-one

patuletin

7-Benzyloxy-2-(3,4-bis-benzyloxy-phenyl)-3,5-dihydroxy-6-methoxy-chromen-4-one

Toluene-4-sulfonic acid 7-benzyloxy-2-(3,4-bis-benzyloxy-phenyl)-5-hydroxy-6-methoxy-4-oxo-4H-chromen-3-yl ester

Refernces