3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acid

Base Information

Chemical Name:3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acid
CAS No.:80900-78-3
Molecular Formula:C₈H₁₃NO₃S
Molecular Weight:203.262
Hs Code.:
Mol file:80900-78-3.mol

Synonyms:MMOPA;3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acid;1-Piperidineacetic acid,3-(mercaptomethyl)-2-oxo;

Suppliers and Price of 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acid

Chemical Property:

Vapor Pressure:2.84E-09mmHg at 25°C
Boiling Point:447.9°Cat760mmHg
Flash Point:224.7°C
PSA：96.41000
Density:1.259g/cm³
LogP:0.17730

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acid

There total 5 articles about 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50585-89-2
3-methoxycarbonylpiperidine

: 80900-78-3
(3-Mercaptomethyl-2-oxo-piperidin-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / K₂CO₃ / 3.5 h / 50 °C

2: 1.) aq. NaOH, 2.) acetic anhydride / 1.) MeOH, 3 d, 2.) reflux, 2 h

3: 75 percent / 72 h

4: 62 percent / CF₃COOH / various solvent(s) / 1 h

5: 25percent aq. NH₄OH / 1 h

With ammonium hydroxide; sodium hydroxide; acetic anhydride; potassium carbonate; trifluoroacetic acid; In various solvent(s);
DOI:10.1021/jm00345a011

Reference yield:

: 80901-01-5
(3-Methylene-2-oxo-piperidin-1-yl)-acetic acid tert-butyl ester

: 80900-78-3
(3-Mercaptomethyl-2-oxo-piperidin-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / 72 h

2: 62 percent / CF₃COOH / various solvent(s) / 1 h

3: 25percent aq. NH₄OH / 1 h

With ammonium hydroxide; trifluoroacetic acid; In various solvent(s);
DOI:10.1021/jm00345a011

Reference yield:

: 80901-00-4
methyl N-<(tert-butyloxycarbonyl)methyl>nipecotate

: 80900-78-3
(3-Mercaptomethyl-2-oxo-piperidin-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) aq. NaOH, 2.) acetic anhydride / 1.) MeOH, 3 d, 2.) reflux, 2 h

2: 75 percent / 72 h

3: 62 percent / CF₃COOH / various solvent(s) / 1 h

4: 25percent aq. NH₄OH / 1 h

With ammonium hydroxide; sodium hydroxide; acetic anhydride; trifluoroacetic acid; In various solvent(s);
DOI:10.1021/jm00345a011