Technology Process of 1H-3-Benzazepine-2-carboxylic acid, 2,3,4,5-tetrahydro-
There total 9 articles about 1H-3-Benzazepine-2-carboxylic acid, 2,3,4,5-tetrahydro- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methyloxirane;
In
ethanol;
at 50 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: CH3COOK, 3 Angstroem molecular sieves / propan-2-ol / 1.) r.t., 15 min, 2.) r.t., 40 min
2: NaBH3CN / propan-2-ol / 15 h / Ambient temperature
3: CH2Cl2 / 1.) ice-bath, 15 min, 2.) r.t., 20 h
4: TsCl, Et3N / CH2Cl2 / 12 h / Ambient temperature
5: 59 percent / Bu4NCl, NaHCO3, 3 Angstroem molecular sieves / Pd(OAc)2 / dimethylformamide / 1.) r.t., 30 min, 2.) 110 deg C, 16 h
6: 98 percent / H2 / 10percent Pd/C / methanol / 24 h
7: 97 percent / 3 M aq. HCl / 4 h / 90 °C
8: 100 percent / propene oxide / ethanol / 4 h / 50 °C
With
hydrogenchloride; 3 A molecular sieve; tetrabutyl-ammonium chloride; hydrogen; potassium acetate; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; p-toluenesulfonyl chloride; methyloxirane;
palladium diacetate; palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: CH2Cl2 / 1.) ice-bath, 15 min, 2.) r.t., 20 h
2: TsCl, Et3N / CH2Cl2 / 12 h / Ambient temperature
3: 59 percent / Bu4NCl, NaHCO3, 3 Angstroem molecular sieves / Pd(OAc)2 / dimethylformamide / 1.) r.t., 30 min, 2.) 110 deg C, 16 h
4: 98 percent / H2 / 10percent Pd/C / methanol / 24 h
5: 97 percent / 3 M aq. HCl / 4 h / 90 °C
6: 100 percent / propene oxide / ethanol / 4 h / 50 °C
With
hydrogenchloride; 3 A molecular sieve; tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; triethylamine; p-toluenesulfonyl chloride; methyloxirane;
palladium diacetate; palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
