4-(3-Bromo-4-methoxyphenyl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 4-(3-Bromo-4-methoxyphenyl)-1,3-thiazol-2-amine
• CAS No.: 189011-00-5
• Molecular Formula: C₁₀H₉BrN₂OS
• Molecular Weight: 285.164
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID10353630
• Wikidata: Q82131337
• Mol file: 189011-00-5.mol

Synonyms:4-(3-bromo-4-methoxyphenyl)-1,3-thiazol-2-amine;189011-00-5;4-(3-Bromo-4-methoxyphenyl)thiazol-2-amine;Cambridge id 5846891;Oprea1_210852;Oprea1_681692;SCHEMBL3147991;4-(3-bromo-4-methoxyphenyl)-1,3-thiazol-2(3H)-imine;DTXSID10353630;MFCD01539893;STK164088;STK845945;AKOS000294654;AKOS005626292;CCG-111945;FT-0753327;EN300-11203;2-Thiazolamine, 4-(3-bromo-4-methoxyphenyl)-;AB00099090-01;AB00099090-02;SR-01000492949;SR-01000492949-1;Z48847622

Chemical Property of 4-(3-Bromo-4-methoxyphenyl)-1,3-thiazol-2-amine

Chemical Property:

• Vapor Pressure: 2.01E-07mmHg at 25°C
• Boiling Point: 424.8oC at 760 mmHg
• Flash Point: 210.7oC
• PSA: 76.38000
• Density: 1.585g/cm3
• LogP: 3.74460
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 283.96190
• Heavy Atom Count: 15
• Complexity: 220

Purity/Quality:

4-(3-BROMO-4-METHOXYPHENYL)-1,3-THIAZOL-2-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C2=CSC(=N2)N)Br

Technology Process of 4-(3-Bromo-4-methoxyphenyl)-1,3-thiazol-2-amine

There total 2 articles about 4-(3-Bromo-4-methoxyphenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-ethylanisole (1515-95-3) → 2-amino-4-(3′-bromo-4′-methoxyphenyl)thiazole (189011-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; water / 10 h / 35 - 40 °C / Irradiation

2: 1 h / 20 °C

With N-Bromosuccinimide; water; 1: |Wohl-Ziegler Bromination;

DOI:10.1002/ejoc.201900100

Reference yield:

2?bromo?1?(3?bromo?4?methoxyphenyl)ethan?1?one (6096-83-9) + thiourea (17356-08-0) → 2-amino-4-(3′-bromo-4′-methoxyphenyl)thiazole (189011-00-5)

Guidance literature:

at 20 ℃; for 1h;

DOI:10.1002/ejoc.201900100

Reference yield:

N-Acetyl-pyridiniumacetat (16411-89-5) + 2-amino-4-(3′-bromo-4′-methoxyphenyl)thiazole (189011-00-5) → N-[4-(3-Bromo-4-methoxy-phenyl)-thiazol-2-yl]-acetamide

Guidance literature:

With pyridine;

upstream raw materials:

2?bromo?1?(3?bromo?4?methoxyphenyl)ethan?1?one

thiourea

p-ethylanisole

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