Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[(4-chloro-2-nitrophenyl)methyl] O-(2-cyanoethyl) phosphorothioate]

Base Information

• Chemical Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[(4-chloro-2-nitrophenyl)methyl] O-(2-cyanoethyl) phosphorothioate]
• CAS No.: 189153-27-3
• Molecular Formula: C41H40ClN4O11PS
• Molecular Weight: 863.282
• Mol file: 189153-27-3.mol

Synonyms:

Chemical Property of Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[(4-chloro-2-nitrophenyl)methyl] O-(2-cyanoethyl) phosphorothioate]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[(4-chloro-2-nitrophenyl)methyl] O-(2-cyanoethyl) phosphorothioate]

There total 4 articles about Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[(4-chloro-2-nitrophenyl)methyl] O-(2-cyanoethyl) phosphorothioate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-chloro-2-nitrobenzyl chloride (938-71-6) + Thiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2-cyano-ethyl) ester; compound with triethyl-amine → Thiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-2-nitro-benzyl) ester O'-(2-cyano-ethyl) ester (189153-27-3)

Guidance literature:

With 2,6-dimethylpyridine; sodium iodide; In acetonitrile; Ambient temperature;

DOI:10.1080/07328319708002529

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] (98796-51-1) → Thiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-2-nitro-benzyl) ester O'-(2-cyano-ethyl) ester (189153-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂O, tetrazole

2: S₈, lutidine / toluene

3: NaI

With 1H-tetrazole; sulfur; lutidine; water; sodium iodide; In toluene;

DOI:10.1080/07328319708006243

Reference yield:

5′-O-(4,4′-dimethoxytrityl)thymidine-3′-O-[2-cyanoethyl]phosphonate (102987-83-7) → Thiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-2-nitro-benzyl) ester O'-(2-cyano-ethyl) ester (189153-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: S₈, lutidine / toluene

2: NaI

With sulfur; lutidine; sodium iodide; In toluene;

DOI:10.1080/07328319708006243

upstream raw materials:

4-chloro-2-nitrobenzyl chloride

5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

5′-O-(4,4′-dimethoxytrityl)thymidine-3′-O-[2-cyanoethyl]phosphonate

Downstream raw materials:

C₄₃H₄₇N₄O₁₄PS

C₅₀H₅₁ClN₅O₁₆PS