D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-[1,6-dihydro-2-[(2-methyl-1 -oxopropyl)amino]-6-oxo-9H-purin-9-yl]-, diphenylmethyl ester, (4R)-

Base Information

Chemical Name:D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-[1,6-dihydro-2-[(2-methyl-1 -oxopropyl)amino]-6-oxo-9H-purin-9-yl]-, diphenylmethyl ester, (4R)-
CAS No.:189163-63-1
Molecular Formula:C44H41N7O7
Molecular Weight:779.852
Hs Code.:

D-Proline,
N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-[1,6-dihydro-2-[(2-methyl-1
-oxopropyl)amino]-6-oxo-9H-purin-9-yl]-, diphenylmethyl ester, (4R)-

Synonyms:

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Chemical Property of D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-[1,6-dihydro-2-[(2-methyl-1 -oxopropyl)amino]-6-oxo-9H-purin-9-yl]-, diphenylmethyl ester, (4R)-

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Purity/Quality:

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Technology Process of D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-[1,6-dihydro-2-[(2-methyl-1 -oxopropyl)amino]-6-oxo-9H-purin-9-yl]-, diphenylmethyl ester, (4R)-

There total 9 articles about D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-4-[1,6-dihydro-2-[(2-methyl-1 -oxopropyl)amino]-6-oxo-9H-purin-9-yl]-, diphenylmethyl ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86060-85-7
Fmoc-Gly-OPfp

: (2R,4R)-4-(2-Isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-pyrrolidine-2-carboxylic acid benzhydryl ester

: 189163-63-1
(2R,4R)-1-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetyl]-4-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-pyrrolidine-2-carboxylic acid benzhydryl ester

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Yield given; Ambient temperature;
DOI:10.1039/a603699f

Reference yield:

: 135042-12-5,946610-68-0
(4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline

: 189163-63-1
(2R,4R)-1-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetyl]-4-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-pyrrolidine-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / ethyl acetate / Ambient temperature

2: PPh₃, DEAD / tetrahydrofuran / Ambient temperature

3: conc. aq. NH₃ / methanol / 1 h / Ambient temperature

4: PPh₃, DEAD / dioxane / 36 h / Ambient temperature

5: DBU, pyridine / Ambient temperature

6: p-TSA*H₂O / acetonitrile / Ambient temperature

7: DIEA, HOBt*H₂O / dimethylformamide / Ambient temperature

With pyridine; ammonium hydroxide; benzotriazol-1-ol; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/a603699f

Reference yield:

: 908093-98-1
diazodiphenylmethane

: 189163-63-1
(2R,4R)-1-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetyl]-4-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-pyrrolidine-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / ethyl acetate / Ambient temperature

2: PPh₃, DEAD / tetrahydrofuran / Ambient temperature

3: conc. aq. NH₃ / methanol / 1 h / Ambient temperature

4: PPh₃, DEAD / dioxane / 36 h / Ambient temperature

5: DBU, pyridine / Ambient temperature

6: p-TSA*H₂O / acetonitrile / Ambient temperature

7: DIEA, HOBt*H₂O / dimethylformamide / Ambient temperature

With pyridine; ammonium hydroxide; benzotriazol-1-ol; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/a603699f