Carbamic acid, (5-(aminoacetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)-, ethyl ester

Base Information

• Chemical Name: Carbamic acid, (5-(aminoacetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)-, ethyl ester
• CAS No.: 132900-42-6
• Molecular Formula: C₁₉H₂₁N₃O₃
• Molecular Weight: 339.394
• DSSTox Substance ID: DTXSID40157845
• Wikidata: Q83026007
• ChEMBL ID: CHEMBL1497437
• Mol file: 132900-42-6.mol

Synonyms:Carbamic acid, (5-(aminoacetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)-, ethyl ester;132900-42-6;CHEMBL1497437;3-Carbethoxyamino-5-aminoacetyl-10,11-dihydro-5H-dibenz(b,f)azepine;Ethyl (5-(aminoacetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)carbamate;ethyl N-[11-(2-aminoacetyl)-5,6-dihydrobenzo[b][1]benzazepin-2-yl]carbamate;ChemDiv1_024422;MLS001206543;SCHEMBL9732095;HMS656G02;DTXSID40157845;HMS2836K12;BDBM50146372;AKOS000548785;NCGC00245320-01;SMR000517203;[5-(2-Amino-acetyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-3-yl]-carbamic acid ethyl ester

Chemical Property of Carbamic acid, (5-(aminoacetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)-, ethyl ester

Chemical Property:

• Vapor Pressure: 1.97E-11mmHg at 25°C
• Boiling Point: 532.8°Cat760mmHg
• Flash Point: 276°C
• Density: 1.277g/cm³
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 339.15829154
• Heavy Atom Count: 25
• Complexity: 485

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)NC1=CC2=C(CCC3=CC=CC=C3N2C(=O)CN)C=C1

Technology Process of Carbamic acid, (5-(aminoacetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)-, ethyl ester

There total 8 articles about Carbamic acid, (5-(aminoacetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

3-carbethoxyamino-5-chloroacetyl-10,11-dihydro-5H-dibenzazepine (78816-66-7) → 3-carbethoxy-5-aminoacetyl-10,11-dihydro-5H-dibenzazepine (132900-42-6)

Guidance literature:

With ammonium hydroxide; In methanol; at 120 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.ejmech.2015.12.018

Reference yield: 68.0%

→ 3-carbethoxy-5-aminoacetyl-10,11-dihydro-5H-dibenzazepine (132900-42-6)

Guidance literature:

Reference yield:

3-amino-10,11-dihydro-5H-dibenzazepine (10464-35-4) → 3-carbethoxy-5-aminoacetyl-10,11-dihydro-5H-dibenzazepine (132900-42-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / 20percent aq. KOH / acetone / 1 h / Heating

2: 97 percent / toluene / 2 h / Heating

3: 68 percent / NH₃ / ethanol / 1.) 55-60 deg C, 4 h, 2.) 140-150 deg C, 4 h

With potassium hydroxide; ammonia; In ethanol; acetone; toluene;

DOI:10.1007/BF00766590

upstream raw materials:

3-carbethoxyamino-5-chloroacetyl-10,11-dihydro-5H-dibenzazepine

3-amino-10,11-dihydro-5H-dibenzazepine

3-amino-5-acetyl-10,11-dihydro-5H-dibenzazepine

3-carbethoxyamino-10,11-dihydro-5H-dibenzazepine