4-Pyrimidinecarboxylic acid, 2-(4-chloro-3-nitrophenyl)-3-[[(2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]- 2-pyrrolidinyl]carbonyl]hexahydro-6-oxo-, 1,1-dimethylethyl ester, (2S,4S)-

Base Information

• Chemical Name: 4-Pyrimidinecarboxylic acid, 2-(4-chloro-3-nitrophenyl)-3-[[(2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]- 2-pyrrolidinyl]carbonyl]hexahydro-6-oxo-, 1,1-dimethylethyl ester, (2S,4S)-
• CAS No.: 189256-38-0
• Molecular Formula: C35H35ClN4O8
• Molecular Weight: 675.138
• Mol file: 189256-38-0.mol

Synonyms:

Chemical Property of 4-Pyrimidinecarboxylic acid, 2-(4-chloro-3-nitrophenyl)-3-[[(2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]- 2-pyrrolidinyl]carbonyl]hexahydro-6-oxo-, 1,1-dimethylethyl ester, (2S,4S)-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyrimidinecarboxylic acid, 2-(4-chloro-3-nitrophenyl)-3-[[(2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]- 2-pyrrolidinyl]carbonyl]hexahydro-6-oxo-, 1,1-dimethylethyl ester, (2S,4S)-

There total 3 articles about 4-Pyrimidinecarboxylic acid, 2-(4-chloro-3-nitrophenyl)-3-[[(2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]- 2-pyrrolidinyl]carbonyl]hexahydro-6-oxo-, 1,1-dimethylethyl ester, (2S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(S)-N-(fluoren-9-ylmethoxycarbonyl)prolyl chloride (103321-52-4) + (S)-2-{[1-(4-Chloro-3-nitro-phenyl)-meth-(E)-ylidene]-amino}-succinamic acid tert-butyl ester (189256-58-4) → (2S,4S)-2-(4-Chloro-3-nitro-phenyl)-3-[(S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-pyrrolidine-2-carbonyl]-6-oxo-hexahydro-pyrimidine-4-carboxylic acid tert-butyl ester (189256-38-0)

Guidance literature:

In pyridine; benzene;

DOI:10.1021/ja9639271

Reference yield:

L-asparagine tert-butyl ester (25456-86-4) → (2S,4S)-2-(4-Chloro-3-nitro-phenyl)-3-[(S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-pyrrolidine-2-carbonyl]-6-oxo-hexahydro-pyrimidine-4-carboxylic acid tert-butyl ester (189256-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / (MeO)3CH

2: 30 percent / pyridine; benzene

With trimethyl orthoformate; In pyridine; benzene;

DOI:10.1021/ja9639271

Reference yield:

4-chloro-3-nitro-benzaldehyde (16588-34-4) → (2S,4S)-2-(4-Chloro-3-nitro-phenyl)-3-[(S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-pyrrolidine-2-carbonyl]-6-oxo-hexahydro-pyrimidine-4-carboxylic acid tert-butyl ester (189256-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / (MeO)3CH

2: 30 percent / pyridine; benzene

With trimethyl orthoformate; In pyridine; benzene;

DOI:10.1021/ja9639271

upstream raw materials:

(S)-N-(fluoren-9-ylmethoxycarbonyl)prolyl chloride

(S)-2-{[1-(4-Chloro-3-nitro-phenyl)-meth-(E)-ylidene]-amino}-succinamic acid tert-butyl ester

L-asparagine tert-butyl ester

4-chloro-3-nitro-benzaldehyde

Refernces