2-Pyridinecarboxylic acid, 5-[(1E)-3-[[[1-[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- 1H-pyrrol-2-yl]methyl]amino]-3-oxo-1-propenyl]-

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Chemical Name:2-Pyridinecarboxylic acid, 5-[(1E)-3-[[[1-[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- 1H-pyrrol-2-yl]methyl]amino]-3-oxo-1-propenyl]-
CAS No.:189268-50-6
Molecular Formula:C31H24Cl2N4O4
Molecular Weight:587.462
Hs Code.:

2-Pyridinecarboxylic acid,
5-[(1E)-3-[[[1-[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]-
1H-pyrrol-2-yl]methyl]amino]-3-oxo-1-propenyl]-

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Chemical Property of 2-Pyridinecarboxylic acid, 5-[(1E)-3-[[[1-[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- 1H-pyrrol-2-yl]methyl]amino]-3-oxo-1-propenyl]-

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Technology Process of 2-Pyridinecarboxylic acid, 5-[(1E)-3-[[[1-[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- 1H-pyrrol-2-yl]methyl]amino]-3-oxo-1-propenyl]-

There total 9 articles about 2-Pyridinecarboxylic acid, 5-[(1E)-3-[[[1-[2,4-dichloro-3-[[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- 1H-pyrrol-2-yl]methyl]amino]-3-oxo-1-propenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.8%

: 189268-49-3
1-[2,4-dichloro-3-(2-methylquinolin-8-yloxymethyl)phenyl]-2-[(E)-3-(6-ethoxycarbonylpyridin-3-yl)acryloylaminomethyl]pyrrole

: 189268-50-6
2-[(E)-3-(6-carboxypyridin-3-yl)acryloylaminomethyl]-1-[2,4-dichloro-3-(2-methylquinolin-8-yloxymethyl)phenyl]pyrrole

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃; for 1h;
DOI:10.1021/jm980330i

Reference yield:

: 160647-01-8
2,6-Dichloro-3-nitrobenzyl alcohol

: 189268-50-6
2-[(E)-3-(6-carboxypyridin-3-yl)acryloylaminomethyl]-1-[2,4-dichloro-3-(2-methylquinolin-8-yloxymethyl)phenyl]pyrrole

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / CH₂Cl₂ / 0.5 h

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

3: 65.8 percent / aq. FeCl₃, carbon, H₂NNH₂ / methanol / 6 h / 70 °C

4: 81.9 percent / AcOH / 4 h / 100 °C

5: 2.) DMF / 1.) CH₂Cl₂, a) -20 deg C, 30 min, b) RT, 1 h, 2.) CH₂Cl₂, a) -78 deg C, 30 min, b) RT, 1 h

6: 52.2 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 0 - 20 °C

7: HOBt, WSCD*HCl / dimethylformamide / 2.5 h / 0 - 20 °C

8: 78.8 percent / 1 N aq. NaOH / ethanol / 1 h / 60 °C

With sodium hydroxide; lithium aluminium tetrahydride; WSCD*HCl; iron(III) chloride; sodium hydride; pyrographite; benzotriazol-1-ol; acetic acid; triethylamine; N,N-dimethyl-formamide; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980330i

Reference yield:

: 149976-78-3
2,6-dichloro-1-methanesulfonyloxymethyl-3-nitrobenzene

: 189268-50-6
2-[(E)-3-(6-carboxypyridin-3-yl)acryloylaminomethyl]-1-[2,4-dichloro-3-(2-methylquinolin-8-yloxymethyl)phenyl]pyrrole

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

2: 65.8 percent / aq. FeCl₃, carbon, H₂NNH₂ / methanol / 6 h / 70 °C

3: 81.9 percent / AcOH / 4 h / 100 °C

4: 2.) DMF / 1.) CH₂Cl₂, a) -20 deg C, 30 min, b) RT, 1 h, 2.) CH₂Cl₂, a) -78 deg C, 30 min, b) RT, 1 h

5: 52.2 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 0 - 20 °C

6: HOBt, WSCD*HCl / dimethylformamide / 2.5 h / 0 - 20 °C

7: 78.8 percent / 1 N aq. NaOH / ethanol / 1 h / 60 °C

With sodium hydroxide; lithium aluminium tetrahydride; WSCD*HCl; iron(III) chloride; sodium hydride; pyrographite; benzotriazol-1-ol; acetic acid; N,N-dimethyl-formamide; hydrazine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980330i