5-Chloro-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carbonyl chloride

Base Information

Chemical Name:5-Chloro-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carbonyl chloride
CAS No.:189308-64-3
Molecular Formula:C11H10Cl2O2
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID60709380
Wikidata:Q82644282

Synonyms:189308-64-3;5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carbonyl chloride;SCHEMBL7626504;DTXSID60709380;5-Chloro-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carbonyl chloride

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Chloro-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carbonyl chloride

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:244.0057849
Heavy Atom Count:15
Complexity:278

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CC2=C(O1)C(=CC(=C2)Cl)C(=O)Cl)C

Technology Process of 5-Chloro-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carbonyl chloride

There total 6 articles about 5-Chloro-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 189308-64-3
5-Chloro-2,2-dimethyl-2,3-dihydro-benzofuran-7-carbonyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / HCl (gas) / Heating

2: 29 percent / K₂CO₃ / acetone / Heating

3: 81.7 percent / N-methylpyrrolidinone / 7 h / Heating

4: 90percent aq. HCOOH / 3 h / Heating

5: NaOH / H₂O / 3 h / Heating

6: SOCl₂ / 3 h / Heating

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium hydroxide; formic acid; thionyl chloride; potassium carbonate; In water; acetone;
DOI:10.1021/jm00080a016

Reference yield:

: 4068-78-4
methyl 5-chloro-2-hydroxybenzoate

: 189308-64-3
5-Chloro-2,2-dimethyl-2,3-dihydro-benzofuran-7-carbonyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: 29 percent / K₂CO₃ / acetone / Heating

2: 81.7 percent / N-methylpyrrolidinone / 7 h / Heating

3: 90percent aq. HCOOH / 3 h / Heating

4: NaOH / H₂O / 3 h / Heating

5: SOCl₂ / 3 h / Heating

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; formic acid; thionyl chloride; potassium carbonate; In water; acetone;
DOI:10.1021/jm00080a016

Reference yield:

: 136954-97-7
5-chloro-3-(2-methylprop-1-en-3-yl)salicylic acid methyl ester

: 189308-64-3
5-Chloro-2,2-dimethyl-2,3-dihydro-benzofuran-7-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 90percent aq. HCOOH / 3 h / Heating

2: NaOH / H₂O / 3 h / Heating

3: SOCl₂ / 3 h / Heating

With sodium hydroxide; formic acid; thionyl chloride; In water;
DOI:10.1021/jm00080a016