Technology Process of 5-bromo-2-chlorothiophene-3-carboxylic acid
There total 1 articles about 5-bromo-2-chlorothiophene-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridinium hydrobromide perbromide; acetic acid;
In
ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 0 - 20 °C
2: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C
3: tetrahydrofuran / 0.5 h / 0 °C
With
diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1248/cpb.c13-00407
- Guidance literature:
-
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 0 - 20 °C
2: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C
3: tetrahydrofuran / 0.5 h / 0 °C
4: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 1 h / -78 - 20 °C
With
triethylsilane; boron trifluoride diethyl etherate; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1248/cpb.c13-00407