(4-Chloro-3-fluorophenyl)hydrazine

Base Information

• Chemical Name: (4-Chloro-3-fluorophenyl)hydrazine
• CAS No.: 189513-52-8
• Molecular Formula: C6H6ClFN2
• Molecular Weight: 160.57700
• European Community (EC) Number: 824-705-5
• Mol file: 189513-52-8.mol

Synonyms:(4-chloro-3-fluorophenyl)hydrazine;189513-52-8;(4Chloro-3-fluorophenyl)hydrazine;SCHEMBL15076832;4-Chloro-3-fluorophenylhydrazine;AKOS010727881;SB76669;Hydrazine, (4-chloro-3-fluorophenyl)-;EN300-97275;HYDRAZINE,(4-CHLORO-3-FLUOROPHENYL)-

Chemical Property of (4-Chloro-3-fluorophenyl)hydrazine

Chemical Property:

• PSA: 38.05000
• LogP: 2.53800
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 160.0203541
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

(4Chloro-?3-?fluorophenyl)?hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1NN)F)Cl
• Uses: (4Chloro-?3-?fluorophenyl)?hydrazine is used to synthesis a series of 6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-ylhydrazines which exhibit moderate anti-cancer activity.

Technology Process of (4-Chloro-3-fluorophenyl)hydrazine

There total 1 articles about (4-Chloro-3-fluorophenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-3-fluoroaniline (367-22-6) → 4-chloro-3-fluorophenylhydrazine (189513-52-8)

Guidance literature:

4-chloro-3-fluoroaniline; With hydrogenchloride; sodium nitrite; In water; at -10 - 20 ℃; for 1h;

With hydrogenchloride; tin(II) chloride dihdyrate; In water; at -10 - 20 ℃; for 2h;

Reference yield: 32.0%

p-acetylaminobenzenesulfonyl chloride (121-60-8) + 4-chloro-3-fluorophenylhydrazine (189513-52-8) → N-(4-{[2-(4-chloro-3-fluorophenyl)hydrazinyl]sulfonyl}phenyl)acetamide (1620001-54-8)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2014.05.084

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) + 4-chloro-3-fluorophenylhydrazine (189513-52-8) → 1-(4-chloro-3-fluorophenyl)-2-(1-(4-fluorophenyl)ethylene)hydrazine

Guidance literature:

With potassium acetate; In ethanol; at 90 ℃;

upstream raw materials:

4-chloro-3-fluoroaniline

Downstream raw materials:

N-(4-{[2-(4-chloro-3-fluorophenyl)hydrazinyl]sulfonyl}phenyl)acetamide

Refernces