(4S)-4β-Acetoxy-4a,5,6,7-tetrahydro-3,4aβ,5β-trimethylnaphtho[2,3-b]furan-9(4H)-one

Base Information

Chemical Name:(4S)-4β-Acetoxy-4a,5,6,7-tetrahydro-3,4aβ,5β-trimethylnaphtho[2,3-b]furan-9(4H)-one
CAS No.:24405-79-6
Molecular Formula:C₁₇H₂₀O₄
Molecular Weight:288.343
Hs Code.:
Mol file:24405-79-6.mol

Synonyms:Eremophila-1(10),7,11-trien-9-one,8,12-epoxy-6b-hydroxy-,acetate (8CI); Naphtho[2,3-b]furan-9(4H)-one,4-(acetyloxy)-4a,5,6,7-tetrahydro-3,4a,5-trimethyl-, [4S-(4a,4aa,5a)]-; Decompostin

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-4β-Acetoxy-4a,5,6,7-tetrahydro-3,4aβ,5β-trimethylnaphtho[2,3-b]furan-9(4H)-one

Chemical Property:

Melting Point:195-196 °C
Boiling Point:392.0±42.0 °C(Predicted)
PSA：56.51000
Density:1.19±0.1 g/cm3(Predicted)
LogP:3.75110

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4S)-4β-Acetoxy-4a,5,6,7-tetrahydro-3,4aβ,5β-trimethylnaphtho[2,3-b]furan-9(4H)-one

There total 10 articles about (4S)-4β-Acetoxy-4a,5,6,7-tetrahydro-3,4aβ,5β-trimethylnaphtho[2,3-b]furan-9(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-24-7
acetic anhydride

: 18883-12-0,24405-80-9,62742-87-4,77286-75-0
(+/-)-6β-hydroxy-1,10-dehydrofuranoeremophilan-9-one

: 24405-79-6,24405-81-0,77286-76-1
(+/-)-decomposition

Guidance literature:: With pyridine; dmap; for 1h; Ambient temperature;
DOI:10.1248/cpb.29.3474

Reference yield:

: 71596-78-6,71629-22-6,77286-77-2,77286-78-3
C₁₇H₂₀O₆

: 24405-79-6,24405-81-0,77286-76-1
(+/-)-decomposition

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / aq. AcOH / 10 h / Ambient temperature

2: 92 percent / pyridine, DMAP

3: 91 percent / BF₃/Et₂O / 0.25 h / Ambient temperature

4: 100 percent / K₂CO₃ / methanol / 0.5 h / Ambient temperature

5: Raney Ni (W-2) / dioxane / 0.03 h / Heating

6: 95 percent / SOCl₂, pyridine / 0.17 h / 0 °C

7: 100 percent / NaBH₄ / methanol / 0 °C

8: 85 percent / pyridine

With pyridine; dmap; sodium tetrahydroborate; thionyl chloride; diethyl ether; Raney Ni (W-2); boron trifluoride; potassium carbonate; acetic acid; In 1,4-dioxane; methanol;

Reference yield:

: 77250-51-2
3,3-ethylenedithio-10α-hydroxyfuranoeremophilan-6,9-dione

: 24405-79-6,24405-81-0,77286-76-1
(+/-)-decomposition

Guidance literature:: Multi-step reaction with 4 steps

1: Raney Ni (W-2) / dioxane / 0.03 h / Heating

2: 95 percent / SOCl₂, pyridine / 0.17 h / 0 °C

3: 100 percent / NaBH₄ / methanol / 0 °C

4: 85 percent / pyridine

With pyridine; sodium tetrahydroborate; thionyl chloride; Raney Ni (W-2); In 1,4-dioxane; methanol;