Technology Process of Propanamide,
N-[2-bromo-3-(methoxymethoxy)-4,6-dimethylphenyl]-2,2-dimethyl-
There total 7 articles about Propanamide,
N-[2-bromo-3-(methoxymethoxy)-4,6-dimethylphenyl]-2,2-dimethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 ℃;
for 3h;
DOI:10.1021/jm9700326
- Guidance literature:
-
Multi-step reaction with 7 steps
1: Et3N / CH2Cl2 / 0.25 h / Ambient temperature
2: conc. H2SO4, HNO3(fuming) / 0.67 h / 0 °C
3: H2 / 10percent Pd/C / ethyl acetate / 24 h / Ambient temperature
4: pyridine / 1 h / 0 °C
5: 10N aq. NaOH / ethanol / 0.5 h / 0 °C
6: Br2 / CH2Cl2 / 0.5 h / 0 °C
7: 89 percent / EtN(i-Pr)2 / CH2Cl2 / 3 h / 0 °C
With
pyridine; sodium hydroxide; sulfuric acid; hydrogen; bromine; nitric acid; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm9700326
- Guidance literature:
-
Multi-step reaction with 6 steps
1: conc. H2SO4, HNO3(fuming) / 0.67 h / 0 °C
2: H2 / 10percent Pd/C / ethyl acetate / 24 h / Ambient temperature
3: pyridine / 1 h / 0 °C
4: 10N aq. NaOH / ethanol / 0.5 h / 0 °C
5: Br2 / CH2Cl2 / 0.5 h / 0 °C
6: 89 percent / EtN(i-Pr)2 / CH2Cl2 / 3 h / 0 °C
With
pyridine; sodium hydroxide; sulfuric acid; hydrogen; bromine; nitric acid; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm9700326
