3'-Fluoro-4'-morpholinoacetophenone

Base Information

• Chemical Name: 3'-Fluoro-4'-morpholinoacetophenone
• CAS No.: 189763-65-3
• Molecular Formula: C12H14FNO2
• Molecular Weight: 223.24300
• DSSTox Substance ID: DTXSID30354528
• Wikidata: Q82132730
• Mol file: 189763-65-3.mol

Synonyms:3'-fluoro-4'-morpholinoacetophenone;189763-65-3;1-(3-fluoro-4-morpholin-4-ylphenyl)ethanone;1-(3-Fluoro-4-morpholinophenyl)ethanone;Ethanone, 1-[3-fluoro-4-(4-morpholinyl)phenyl]-;1-[3-fluoro-4-(morpholin-4-yl)phenyl]ethan-1-one;MFCD00543914;3`-Fluoro-4`-morpholinoacetophenone;Cambridge id 5119000;1-[3-fluoro-4-(morpholin-4-yl)phenyl]ethanone;SCHEMBL6955366;DTXSID30354528;KIMOECSFZWTBMK-UHFFFAOYSA-N;AMY20283;STK360709;AKOS000221561;CCG-291094;AS-31744;SY004886;1-(3-fluoro-4-morpholinophenyl)ethan-1-one;CS-0208327;EN300-07759;1-[3-Fluoro-4-(4-morpholinyl)phenyl]ethanone;1-[3-Fluoro-4-morpholin-4-ylphenyl]-ethanone;A880441;SR-01000421983;J-504100;SR-01000421983-1;Z57122137;3 inverted exclamation mark -Fluoro-4 inverted exclamation mark -morpholinoacetophenone

Chemical Property of 3'-Fluoro-4'-morpholinoacetophenone

Chemical Property:

• PSA: 29.54000
• LogP: 1.92990
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 223.10085685
• Heavy Atom Count: 16
• Complexity: 253

Purity/Quality:

98%min ^*data from raw suppliers

3''-Fluoro-4''-morpholinoacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC(=C(C=C1)N2CCOCC2)F

Technology Process of 3'-Fluoro-4'-morpholinoacetophenone

There total 1 articles about 3'-Fluoro-4'-morpholinoacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

morpholine (110-91-8,99108-56-2) + 3',4'-difluoroacetophenone (369-33-5) → 1-[3-fluoro-4-(morpholin-4-yl)phenyl]ethanone (189763-65-3)

Guidance literature:

With dipotassium peroxodisulfate; water; silver carbonate; at 120 ℃; Sealed tube;

DOI:10.1039/c8ob01749b

Reference yield:

1-[3-fluoro-4-(morpholin-4-yl)phenyl]ethanone (189763-65-3) → C25H23F4N3O2

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol

2: sulfuric acid / methanol

With sulfuric acid; sodium hydroxide; In methanol; ethanol;

Reference yield:

1-[3-fluoro-4-(morpholin-4-yl)phenyl]ethanone (189763-65-3) → C25H21F4N3O2

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol

2: sulfuric acid / methanol

3: oxygen; acetic acid; palladium diacetate

With sulfuric acid; oxygen; palladium diacetate; acetic acid; sodium hydroxide; In methanol; ethanol;

upstream raw materials:

morpholine

3',4'-difluoroacetophenone

Refernces

• 1、 Wang, Yu,Wei, Chenlong,Tang, Ruyun,Zhan, Haosheng,Lin, Jing,Liu, Zhenhua,Tao, Weihua,Fang, Zhongxue. "Silver-catalyzed intermolecular amination of fluoroarenes". supporting information. p. 6191 - 6194. Retrieved 2018/09/10.