2-(3,4-Dimethoxyphenyl)-7-methoxy-3-methyl-5-[(E)-1-propenyl]benzofuran

Base Information

Chemical Name:2-(3,4-Dimethoxyphenyl)-7-methoxy-3-methyl-5-[(E)-1-propenyl]benzofuran
CAS No.:41365-37-1
Molecular Formula:C21H22O4
Molecular Weight:338.4
Hs Code.:
Mol file:41365-37-1.mol

Synonyms:(E)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-methyl-5-(prop-1-en-1-yl)benzofuran;2-(3,4-Dimethoxy-phenyl)-7-methoxy-3-methyl-5-((E)-propenyl)-benzofuran;eupomatenoid-12;

Suppliers and Price of 2-(3,4-Dimethoxyphenyl)-7-methoxy-3-methyl-5-[(E)-1-propenyl]benzofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3,4-Dimethoxyphenyl)-7-methoxy-3-methyl-5-[(E)-1-propenyl]benzofuran

Chemical Property:

PSA：40.83000
LogP:5.46710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(3,4-Dimethoxyphenyl)-7-methoxy-3-methyl-5-[(E)-1-propenyl]benzofuran

There total 14 articles about 2-(3,4-Dimethoxyphenyl)-7-methoxy-3-methyl-5-[(E)-1-propenyl]benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: (E)-1-(3,4-dimethoxyphenyl)-2-(2-hydroxy-3-methoxy-5-(prop-1-en-1-yl)phenyl)propan-1-one

: 41365-37-1
(E)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-methyl-5-(prop-1-en-1-yl)benzofuran

Guidance literature:: With trifluoroacetic acid; In chloroform-d1; Inert atmosphere;
DOI:10.1002/anie.201309987

Reference yield:

: 105494-65-3,66680-85-1,66680-84-0
(E)-propenyl-tri-n-butylstannane

: 183370-20-9
2-(3,4-Dimethoxy-phenyl)-5-iodo-7-methoxy-3-methyl-benzofuran

: 41365-37-1
(E)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-methyl-5-(prop-1-en-1-yl)benzofuran

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; lithium chloride; In N,N-dimethyl-formamide; at 120 - 130 ℃; Yield given;
DOI:10.1016/0040-4039(96)01619-X

Reference yield:

: 6379-72-2
1,2-dimethoxy-4-(E)-propenylbenzene

: 41365-37-1
(E)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-methyl-5-(prop-1-en-1-yl)benzofuran

Guidance literature:: Multi-step reaction with 8 steps

1: BF₃*Et₂O / CH₂Cl₂ / -78 °C

2: KOtBu / tetrahydrofuran / 60 - 70 °C

3: Na, anthracene / tetrahydrofuran / 23 °C

4: F₃CCO₂H / CH₂Cl₂ / 23 °C

5: 1.) NaNO₂, 50percent aq. HOAc, 2.) K₂CO₃ / 1.) 0 deg C, 2.) water, 0 deg C

6: Me₃SiCl, NaI / acetonitrile

7: 73 percent / DDQ / benzene / 60 - 70 °C

8: Pd₂(dba)3, (2-furyl)3P, LiCl / dimethylformamide / 120 - 130 °C

With chloro-trimethyl-silane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; anthracene; boron trifluoride diethyl etherate; potassium tert-butylate; sodium; potassium carbonate; acetic acid; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; lithium chloride; sodium nitrite; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/0040-4039(96)01619-X