Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy-

Base Information

• Chemical Name: Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy-
• CAS No.: 84283-08-9
• Molecular Formula: C22H22 N6 O4
• Molecular Weight: 434.454
• Mol file: 84283-08-9.mol

Synonyms:N-(Deoxyguanosin-8-yl)-4-aminobiphenyl

Chemical Property of Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy-

Chemical Property:

• Melting Point: 278°C dec.
• Boiling Point: 792.2oC at 760 mmHg
• PKA: 9.15±0.20(Predicted)
• Flash Point: 432.9oC
• PSA: 151.31000
• Density: 1.61±0.1 g/cm3(Predicted)
• LogP: 2.40730
• Storage Temp.: -20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

N-(2’-Deoxyguanosin-8-yl)-4-aminobiphenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The DNA adduct of 4-Aminobiphenyl.

Technology Process of Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy-

There total 17 articles about Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(2'-deoxyguanosin-8-yl)-4-benzoylaminobiphenyl (475473-90-6) → N-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl (84283-08-9)

Guidance literature:

With sodium carbonate; In methanol; at 20 ℃; for 7h;

DOI:10.1081/NCN-120006832

Reference yield: 69.0%

8-[(1,1'-biphenyl)-4-ylamino]-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine (769141-99-3) → N-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl (84283-08-9)

Guidance literature:

With pyridine hydrogenfluoride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/ja0487022

Reference yield: 6.0%

2'-Deoxyguanosine (961-07-9) + N-(4-Biphenylyl)-O-pivaloylhydroxylamin (119273-48-2) → 2-(N'-Biphenyl-4-yl-hydrazino)-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one (117205-56-8) + N-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl (84283-08-9)

Guidance literature:

With triethylamine; In ethanol; chloroform; water; at 37 ℃; for 1h;

upstream raw materials:

2'-Deoxyguanosine

N-(4-Biphenylyl)-O-pivaloylhydroxylamin

p-biphenylylnitrenium cation

N-(2'-deoxyguanosin-8-yl)-4-benzoylaminobiphenyl

Downstream raw materials:

N₂-formamidino-8N-(4-biphenylamino)-2'-deoxyguanosine