1,4-Benzodioxin-2,3-dicarboxylic acid, 6-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethoxy]-, diethyl ester

Base Information

Chemical Name:1,4-Benzodioxin-2,3-dicarboxylic acid, 6-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethoxy]-, diethyl ester
CAS No.:189818-40-4
Molecular Formula:C₂₄H₂₆ClNO₈
Molecular Weight:491.925
Hs Code.:
Mol file:189818-40-4.mol

Synonyms:

Suppliers and Price of 1,4-Benzodioxin-2,3-dicarboxylic acid, 6-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethoxy]-, diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,4-Benzodioxin-2,3-dicarboxylic acid, 6-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethoxy]-, diethyl ester

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,4-Benzodioxin-2,3-dicarboxylic acid, 6-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethoxy]-, diethyl ester

There total 6 articles about 1,4-Benzodioxin-2,3-dicarboxylic acid, 6-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethoxy]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 587-04-2
m-Chlorobenzaldehyde

: 189818-40-4
6-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-ethoxy}-benzo[1,4]dioxine-2,3-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) zinc iodide; 2.) lithium aluminum hydride / 1.) r.t., 20 min; 2.) Et₂O, reflux, 2 h

2: 70 percent / sodium cyanoborohydride, zinc chloride / methanol / Ambient temperature

With lithium aluminium tetrahydride; sodium cyanoborohydride; zinc(II) iodide; zinc(II) chloride; In methanol;

Reference yield:

: 189818-31-3
6-hydroxy-1,4-benzodioxin-2-carboxylic acid ethyl ester

: 189818-40-4
6-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-ethoxy}-benzo[1,4]dioxine-2,3-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / potassium carbonate, tetrabutylammonium bromide / toluene / 48 h / Heating

2: 90 percent / 1.) 10percent sodium hydroxide; 2.) 2N HCl / ethanol / 2 h / Ambient temperature

3: 1.) 2M lithium diisoproylamide / tetrahydrofuran / 1.) -78 deg C, 4 h; 2.) -78 deg C, 30 min then up to r.t

4: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature

5: conc. hydrochloric acid / dioxane / Ambient temperature

6: 70 percent / sodium cyanoborohydride, zinc chloride / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; tetrabutylammomium bromide; sodium cyanoborohydride; potassium carbonate; triphenylphosphine; zinc(II) chloride; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene;

Reference yield:

: 189818-34-6
6-(2,2-diethoxyethoxy)-1,4-benzodioxine-2-carboxylic acid

: 189818-40-4
6-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-ethoxy}-benzo[1,4]dioxine-2,3-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 2M lithium diisoproylamide / tetrahydrofuran / 1.) -78 deg C, 4 h; 2.) -78 deg C, 30 min then up to r.t

2: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 2 h / Ambient temperature

3: conc. hydrochloric acid / dioxane / Ambient temperature

4: 70 percent / sodium cyanoborohydride, zinc chloride / methanol / Ambient temperature

With hydrogenchloride; sodium cyanoborohydride; triphenylphosphine; zinc(II) chloride; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol;