2-Butenoic acid, 4-[5-(aminocarbonyl)-3-pyridinyl]-3-[1-[(4-methylphenyl)sulfonyl]-1H-imid azol-4-yl]-, ethyl ester, (E)-

Base Information

• Chemical Name: 2-Butenoic acid, 4-[5-(aminocarbonyl)-3-pyridinyl]-3-[1-[(4-methylphenyl)sulfonyl]-1H-imid azol-4-yl]-, ethyl ester, (E)-
• CAS No.: 189936-33-2
• Molecular Formula: C22H22N4O5S
• Molecular Weight: 454.506
• Mol file: 189936-33-2.mol

Synonyms:

Chemical Property of 2-Butenoic acid, 4-[5-(aminocarbonyl)-3-pyridinyl]-3-[1-[(4-methylphenyl)sulfonyl]-1H-imid azol-4-yl]-, ethyl ester, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Butenoic acid, 4-[5-(aminocarbonyl)-3-pyridinyl]-3-[1-[(4-methylphenyl)sulfonyl]-1H-imid azol-4-yl]-, ethyl ester, (E)-

There total 3 articles about 2-Butenoic acid, 4-[5-(aminocarbonyl)-3-pyridinyl]-3-[1-[(4-methylphenyl)sulfonyl]-1H-imid azol-4-yl]-, ethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → (E)-4-(5-Carbamoyl-pyridin-3-yl)-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-but-2-enoic acid ethyl ester (189936-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / NEt₃ / dioxane / Ambient temperature

2: dioxane / 3 h / Heating

With triethylamine; In 1,4-dioxane;

DOI:10.1002/chem.19970030312

Reference yield:

5-[2-(3H-Imidazol-4-yl)-2-oxo-ethyl]-nicotinamide (189936-31-0) → (E)-4-(5-Carbamoyl-pyridin-3-yl)-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-but-2-enoic acid ethyl ester (189936-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / NEt₃ / dioxane / Ambient temperature

2: dioxane / 3 h / Heating

With triethylamine; In 1,4-dioxane;

DOI:10.1002/chem.19970030312

Reference yield:

ethyl (triphenylphosphoranylidene)acetate (1099-45-2) + 5-{2-Oxo-2-[3-(toluene-4-sulfonyl)-3H-imidazol-4-yl]-ethyl}-nicotinamide → (Z)-4-(5-Carbamoyl-pyridin-3-yl)-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-but-2-enoic acid ethyl ester (189936-35-4) + (E)-4-(5-Carbamoyl-pyridin-3-yl)-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-but-2-enoic acid ethyl ester (189936-33-2)

Guidance literature:

In 1,4-dioxane; for 3h; Yield given. Yields of byproduct given; Heating;

DOI:10.1002/chem.19970030312

upstream raw materials:

ethyl (triphenylphosphoranylidene)acetate

p-toluenesulfonyl chloride

5-[2-(3H-Imidazol-4-yl)-2-oxo-ethyl]-nicotinamide