1H-Imidazole-1-carboxylic acid, 4,5-dihydro-4-phenyl-, phenylmethyl ester, (S)-

Base Information

Chemical Name:1H-Imidazole-1-carboxylic acid, 4,5-dihydro-4-phenyl-, phenylmethyl ester, (S)-
CAS No.:190393-69-2
Molecular Formula:C17H16N2O2
Molecular Weight:280.326
Hs Code.:

Synonyms:

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Chemical Property of 1H-Imidazole-1-carboxylic acid, 4,5-dihydro-4-phenyl-, phenylmethyl ester, (S)-

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Technology Process of 1H-Imidazole-1-carboxylic acid, 4,5-dihydro-4-phenyl-, phenylmethyl ester, (S)-

There total 7 articles about 1H-Imidazole-1-carboxylic acid, 4,5-dihydro-4-phenyl-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 190393-67-0
(S)-4-phenyl-Δ²-imidazoline

: 190393-69-2
(S)-N-(benzyloxycarbonyl)-4-phenyl-Δ²-imidazoline

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/jo962343e

Reference yield:

: 2935-35-5
(S)-2-phenylglycine

: 190393-69-2
(S)-N-(benzyloxycarbonyl)-4-phenyl-Δ²-imidazoline

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / LiAlH₄ / tetrahydrofuran / Heating

2: 90 percent / NaHCO₃ / CH₂Cl₂ / 20 °C

3: 98 percent / Et₃N / CH₂Cl₂ / 0.33 h / 20 °C

4: 78 percent / NaN₃, nBu₄NBr / toluene; H₂O / 85 - 90 °C

5: H₂, MeOH-HCl / Pd/C / 24 h / 4654.3 Torr / Ambient temperature

6: 90 percent / 60 - 65 °C

7: 68 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; methanol; lithium aluminium tetrahydride; sodium azide; tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jo962343e

Reference yield:

: 130406-31-4
benzyl (S)-(2-hydroxy-1-phenylethyl)carbamate

: 190393-69-2
(S)-N-(benzyloxycarbonyl)-4-phenyl-Δ²-imidazoline

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 0.33 h / 20 °C

2: 78 percent / NaN₃, nBu₄NBr / toluene; H₂O / 85 - 90 °C

3: H₂, MeOH-HCl / Pd/C / 24 h / 4654.3 Torr / Ambient temperature

4: 90 percent / 60 - 65 °C

5: 68 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; methanol; sodium azide; tetrabutylammomium bromide; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; water; toluene;
DOI:10.1021/jo962343e