cephamycin C

Base Information

• Chemical Name: cephamycin C
• CAS No.: 38429-35-5
• Molecular Formula: C₁₆H₂₂N₄O₉S
• Molecular Weight: 446.438
• NSC Number: 179170
• DSSTox Substance ID: DTXSID301100850
• Nikkaji Number: J3.030.642B
• Wikidata: Q105159121
• Mol file: 38429-35-5.mol

Synonyms:A 16886B;A-16886B;A16886B;cephamycin C;cephamycin C sodium;cephamycin C, (6R)-isomer;cephamycin C, (6R-(6alpha,7alpha,7(R*)))-isomer;cephamycin C, (6R-(6alpha,7alpha,7(S*)))-isomer;cephamycin C, monosodium salt;cephamycin C, sodium salt

Chemical Property of cephamycin C

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 898.2°Cat760mmHg
• Flash Point: 497°C
• PSA: 241.36000
• Density: 1.61g/cm³
• LogP: 0.36890
• XLogP3: -4.3
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 11
• Exact Mass: 446.11074947
• Heavy Atom Count: 30
• Complexity: 802

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1(C2N(C1=O)C(=C(CS2)COC(=O)N)C(=O)O)NC(=O)CCCC(C(=O)O)N
• General Description: Cephamycin, also known as A16886b, is a β-lactam antibiotic structurally related to cephalosporins but distinguished by the presence of a 7α-methoxy group, which enhances its stability against β-lactamases. The synthesized derivatives in this study, particularly those with a five-membered heterocyclic ring in the acylamido side chain, demonstrated potent antibacterial activity, with some compounds rivaling or surpassing the efficacy of cefoxitin and cephalothin against gram-negative bacteria. This highlights the potential of cephamycin derivatives as promising candidates for combating resistant bacterial infections.

Technology Process of cephamycin C

There total 1 articles about cephamycin C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (6R)-7t-((R)-5-amino-5-carboxy-pentanoylamino)-3-carbamoyloxymethyl-7c-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (32178-84-0,34279-51-1,38429-35-5,39212-31-2,64162-09-0)

Guidance literature:

Streptomyces Lactamdurans (MA 2908);

Refernces

Synthesis of 7α methoxy 7 [2 (substituted thio)acetamido]cephalosporin derivatives and their antibacterial activities

10.1248/cpb.24.2629

The research focused on the synthesis and antibacterial activities of 7a-methoxy-7-[2-(substituted thio)acetamido]cephalosporin derivatives. The purpose was to develop more active cephalosporin derivatives by nucleophilic displacement of the halogen atom of 7β-(2-halogenoacetamido)-7-methoxy cephalosporanic acid derivatives with various mercapto compounds. The study concluded that the synthesized compounds, particularly those with a five-membered heterocyclic ring in the acylamido group, exhibited potent antibacterial activities, with compound (6) showing activities comparable to the semi-synthetic antibiotic cefoxitin and superior to cephalothin against gram-negative bacteria. Key chemicals used in the process included cephamycin C, tert-butoxycarbonyl azide, diphenyldiazomethane, chloroacetyl chloride, bis(trimethylsilyl)trifluoroacetamide, and various mercapto compounds for the nucleophilic displacement reaction.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 38429-35-5 Cephamycin

Send

Send

Metric Ton KG G Pound L ML

Send

Send