benzyl N-[1-[[1-[[3-benzylsulfanyl-1-[2-[[1-(carbamoylmethylcarbamoyl)-3-methyl-butyl]carbamoyl]pyrrolidin-1-yl]-1-oxo-propan-2-yl]carbamoyl]-2-carbamoyl-ethyl]carbamoyl]-3-carbamoyl-propyl]carbamate

Base Information

• Chemical Name: benzyl N-[1-[[1-[[3-benzylsulfanyl-1-[2-[[1-(carbamoylmethylcarbamoyl)-3-methyl-butyl]carbamoyl]pyrrolidin-1-yl]-1-oxo-propan-2-yl]carbamoyl]-2-carbamoyl-ethyl]carbamoyl]-3-carbamoyl-propyl]carbamate
• CAS No.: 21688-11-9
• Molecular Formula: C40H55N9O10S
• Molecular Weight: 853.984
• Mol file: 21688-11-9.mol

Synonyms:N2-benzyloxycarbonyl-glutaminyl=>asparaginyl=>S-benzyl-cysteinyl=>prolyl=>leucyl=>-glycin-amide;benzyloxycarbonyl-L-glutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-prolyl-L-leucyl-glycinamide;Z-L-LEUCYL-L-METHIONINE;N-Z-L-Leu-L-Met-OH;Benzyloxycarbonyl-Leu-Met;

Chemical Property of benzyl N-[1-[[1-[[3-benzylsulfanyl-1-[2-[[1-(carbamoylmethylcarbamoyl)-3-methyl-butyl]carbamoyl]pyrrolidin-1-yl]-1-oxo-propan-2-yl]carbamoyl]-2-carbamoyl-ethyl]carbamoyl]-3-carbamoyl-propyl]carbamate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 206 °C
• Boiling Point: 1298.7°Cat760mmHg
• PKA: 10.95±0.46(Predicted)
• Flash Point: 739.2°C
• PSA: 329.61000
• Density: 1.311g/cm³
• LogP: 3.44200

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl N-[1-[[1-[[3-benzylsulfanyl-1-[2-[[1-(carbamoylmethylcarbamoyl)-3-methyl-butyl]carbamoyl]pyrrolidin-1-yl]-1-oxo-propan-2-yl]carbamoyl]-2-carbamoyl-ethyl]carbamoyl]-3-carbamoyl-propyl]carbamate

There total 10 articles about benzyl N-[1-[[1-[[3-benzylsulfanyl-1-[2-[[1-(carbamoylmethylcarbamoyl)-3-methyl-butyl]carbamoyl]pyrrolidin-1-yl]-1-oxo-propan-2-yl]carbamoyl]-2-carbamoyl-ethyl]carbamoyl]-3-carbamoyl-propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N2-benzyloxycarbonyl-glutaminyl=>asparaginyl=>S-benzyl-cysteinyl=>prolyl=>leucyl=>-glycin-amide (21688-11-9)

Guidance literature:

ueber mehrere Stufen;

DOI:10.1021/ja01530a040

Reference yield:

Cbz-L-Gln (2650-64-8) → N2-benzyloxycarbonyl-glutaminyl=>asparaginyl=>S-benzyl-cysteinyl=>prolyl=>leucyl=>-glycin-amide (21688-11-9)

Guidance literature:

Multi-step reaction with 4 steps

1: chlorocarbonic acid ethyl ester; triethylamine; THF / Reagens 4: H₂O

2: DMF; N₂H₄+H₂O

3: acetic acid; NaNO₂; aqueous HCl

4: DMF

With tetrahydrofuran; hydrogenchloride; chloroformic acid ethyl ester; hydrazine hydrate; acetic acid; triethylamine; N,N-dimethyl-formamide; sodium nitrite;

DOI:10.1002/hlca.19550380622

Reference yield:

Z-Gln-Asn-OH (55559-28-9) → N2-benzyloxycarbonyl-glutaminyl=>asparaginyl=>S-benzyl-cysteinyl=>prolyl=>leucyl=>-glycin-amide (21688-11-9)

Guidance literature:

With diphosphorous acid tetraethyl ester; N,N-dimethyl-formamide;

upstream raw materials:

S-benzyl-N-[N²-(N²-benzyloxycarbonyl-L-glutaminyl)-L-asparaginyl]-L-cysteine

S-benzyl-N-[N²-(N²-benzyloxycarbonyl-L-glutaminyl)-L-asparaginyl]-L-cysteinyl azide

N-(N-L-prolyl-L-leucyl)-glycin-amide

Z-Gln-Asn-OH

Downstream raw materials:

glutaminyl=>asparaginyl=>S-benzyl-cysteinyl=>prolyl=>leucyl=>-glycin-amide