N-Formyl-L-sarcolysin

Base Information

• Chemical Name: N-Formyl-L-sarcolysin
• CAS No.: 26367-45-3
• Deprecated CAS: 32526-17-3
• Molecular Formula: C14H18 Cl2 N2 O3
• Molecular Weight: 333.215
• NSC Number: 39274,37024
• DSSTox Substance ID: DTXSID00954256
• Nikkaji Number: J514.309H
• Mol file: 26367-45-3.mol

Synonyms:N-Formyl-L-sarcolysin;N-Formylmelphalan;N-Formylsarcolysine;CB 3208;N-Formyl-L-p-sarcolysin;NSC 37024;L-3-(p-(Bis(2-chloroethyl)amino)phenyl)-N-formylalanine;L-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-;Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-, (-)-;ALANINE, 3-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-N-FORMYL-, L-;L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-N-formyl-;DL-Phenylalanine, 4-[bis(2-chloroethyl)amino]-N-formyl-;L-Alanine, 3-(p-[bis(2-chloroethyl)amino]phenyl)-N-formyl-;C14H18Cl2N2O3;L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-formyl-;Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-N-formyl-, L-;NFormylmelphalan;C14-H18-Cl2-N2-O3;N-Formyl-DL-sarcolysin;26367-45-3;Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-N-formyl-, DL-;DTXSID00954256;NSC37024;NSC39274;MP 506;NSC-37024;NSC-39274;LS-15879;HY-147327;CS-0565883;DL-Alanine, 3-[p-bis(2-chloroethyl)aminophenyl]-N-formyl-;4-[Bis(2-chloroethyl)amino]-N-(hydroxymethylidene)phenylalanine;32526-17-3

Chemical Property of N-Formyl-L-sarcolysin

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 332.0694478
• Heavy Atom Count: 21
• Complexity: 317

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)O)NC=O)N(CCCl)CCCl

Technology Process of N-Formyl-L-sarcolysin

There total 1 articles about N-Formyl-L-sarcolysin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

melphalan (531-76-0,8057-25-8) + 2,3,4-pentanetrione (921-11-9) → N-formylsarcolysine (26367-45-3)

Guidance literature:

With formic acid;

DOI:10.1016/S0960-894X(01)00260-8

Reference yield: 70.0%

N-formylsarcolysine (26367-45-3) + Nω-nitroarginyl-tryptophyl-glycine methyl ester hydrochloride → N-formyl-D-sarcolysyl-Nω-nitroarginyl-tryptophyl-glycine methyl ester (85642-30-4) + N-formyl-L-sarcolysyl-Nω-nitroarginyl-tryptophyl-glycine methyl ester (85642-29-1)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 19h; Ambient temperature;

Reference yield: 60.0%

N-formylsarcolysine (26367-45-3) + Nε-Z-lysyl-tryptophyl-glycine methyl ester hydrochloride → N-formyl-D-sarcolysyl-Nε-Z-lysyl-tryptophyl-glycine methyl ester (85642-41-7) + N-formyl-L-sarcolysyl-Nε-Z-lysyl-tryptophyl-glycine methyl ester (85642-40-6)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 4 ℃; for 24h;

upstream raw materials:

melphalan

2,3,4-pentanetrione

Downstream raw materials:

N-{4-[bis-(2-chloro-ethyl)-amino]-N-formyl-phenylalanyl}-glycine ethyl ester

N^α-{4-[bis-(2-chloro-ethyl)-amino]-N-formyl-phenylalanyl}-tryptophan-methyl ester

4-[bis-(2-chloro-ethyl)-amino]-N-formyl-phenylalanine [1,3,4]thiadiazol-2-ylamide

3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-formylamino-propionic acid 4-nitro-phenyl ester