Phosphoric acid, 2-[(1-oxooctadecyl)amino]-3-phenoxypropyl bis(phenylmethyl) ester, (R)-

Base Information

• Chemical Name: Phosphoric acid, 2-[(1-oxooctadecyl)amino]-3-phenoxypropyl bis(phenylmethyl) ester, (R)-
• CAS No.: 192506-26-6
• Molecular Formula: C₄₁H₆₀NO₆P
• Molecular Weight: 693.904
• Mol file: 192506-26-6.mol

Synonyms:

Chemical Property of Phosphoric acid, 2-[(1-oxooctadecyl)amino]-3-phenoxypropyl bis(phenylmethyl) ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid, 2-[(1-oxooctadecyl)amino]-3-phenoxypropyl bis(phenylmethyl) ester, (R)-

There total 3 articles about Phosphoric acid, 2-[(1-oxooctadecyl)amino]-3-phenoxypropyl bis(phenylmethyl) ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

phosphoric acid dibenzyl ester (1623-08-1) + (2S)-(-)-1-octadecanoyl-2-(phenoxymethyl)aziridine (192506-20-0) → dibenzyl (2R)-3-phenoxy-1-(octadecanoylamino)propan-2-yl phosphate (192506-27-7) + dibenzyl (2R)-3-phenoxy-2-(octadecanoylamino)propan-1-yl phosphate (192506-26-6)

Guidance literature:

In dichloromethane; at -15 ℃; for 2.5h;

DOI:10.1021/jo962298a

Reference yield:

(2R)-1,2-epoxy-3-phenoxypropane (71031-03-3,71031-02-2) → dibenzyl (2R)-3-phenoxy-2-(octadecanoylamino)propan-1-yl phosphate (192506-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) NaN₃, ammonium sulfate, 2) PPh₃ / 1) methoxyethanol, H₂O, 16 h, 2) CH₃CN, reflux, 6 h

2: 97 percent / Et₃N / CH₂Cl₂ / 3 h

3: 70 percent / CH₂Cl₂ / 2.5 h / -15 °C

With ammonium sulfate; sodium azide; triethylamine; triphenylphosphine; In dichloromethane;

DOI:10.1021/jo962298a

Reference yield:

(2S)-(+)-2-(phenoxymethyl)aziridine (192506-16-4) → dibenzyl (2R)-3-phenoxy-2-(octadecanoylamino)propan-1-yl phosphate (192506-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Et₃N / CH₂Cl₂ / 3 h

2: 70 percent / CH₂Cl₂ / 2.5 h / -15 °C

With triethylamine; In dichloromethane;

DOI:10.1021/jo962298a

upstream raw materials:

phosphoric acid dibenzyl ester

(2S)-(-)-1-octadecanoyl-2-(phenoxymethyl)aziridine

(2R)-1,2-epoxy-3-phenoxypropane

(2S)-(+)-2-(phenoxymethyl)aziridine