2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl

Base Information

• Chemical Name: 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl
• CAS No.: 98966-14-4
• Molecular Formula: C₁₆H₁₆N₂O₄
• Molecular Weight: 300.314
• Mol file: 98966-14-4.mol

Synonyms:DiOH-diAcNH-biphenyl;Acetaminophen Dimer;Paracetamol Dimer Impurity;5,5'-diacetamino-2,2'-biphenol;paracetamol dimer;

Chemical Property of 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl

Chemical Property:

• Melting Point: >148oC (dec.)
• Boiling Point: 642.2°Cat760mmHg
• PKA: 8.96±0.43(Predicted)
• Flash Point: 342.2°C
• PSA: 105.64000
• Density: 1.379g/cm³
• LogP: 3.98060
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

AcetaminophenDimer ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Acetaminophen Dimer is an oxidatively couple dimer of Acetaminaphen (A161220). Acetaminophen Dimer along with other p-acetamidophenol analogs were used to determine peroxidase activities.

Technology Process of 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl

There total 2 articles about 2,2'-dihydroxy-5,5'-diacetyldiaminebiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-acetaminophenol (103-90-2,8055-08-1) → 5,5'-diacetamino-2,2'-biphenol (98966-14-4)

Guidance literature:

With 5,10,15,20-tetrakis(4-methoxyphenyl)-21H,23H-porphine cobalt(II); oxygen; sodium carbonate; In methanol; water; at 60 ℃; for 32h; under 760.051 Torr; Schlenk technique; Sealed tube;

DOI:10.1002/ejoc.201201595

Reference yield:

→ 5,5'-diacetamino-2,2'-biphenol (98966-14-4)

Guidance literature:

Acetaminophen (2), K3Fe(CN)6;

DOI:10.1248/yakushi1947.94.5_633

upstream raw materials:

4-acetaminophenol

Refernces

• 1、 Yu, Donghui,Van Antwerpen, Pierre,Patris, Stephanie,Blankert, Bertrand,Kauffmann, Jean-Michel. "Enzyme Immobilized Magnetic Nanoparticles for in-line capillary electrophoresis and drug biotransformation studies: Application to paracetamol". . p. 455 - 460. Retrieved 2010.
• 2、 Jiang, Qing,Sheng, Wenbing,Tian, Mi,Tang, Jie,Guo, Cancheng. "Cobalt(II)-porphyrin-catalyzed aerobic oxidation: Oxidative coupling of phenols". supporting information. p. 1861 - 1866. Retrieved 2013/04/24.