2-Amino-2-benzyl-3-phenylpropanoic acid

Base Information

• Chemical Name: 2-Amino-2-benzyl-3-phenylpropanoic acid
• CAS No.: 6278-96-2
• Molecular Formula: C16H17 N O2
• Molecular Weight: 255.316
• NSC Number: 34508
• DSSTox Substance ID: DTXSID50978442
• Nikkaji Number: J678.034B
• ChEMBL ID: CHEMBL4247302
• Mol file: 6278-96-2.mol

Synonyms:2-amino-2-benzyl-3-phenylpropanoic acid;6278-96-2;NSC34508;alpha-Benzylphenylalanine;SCHEMBL8351006;CHEMBL4247302;DTXSID50978442;GBKZHNIMMJPKLO-UHFFFAOYSA-N;2-amino-2,2-bisbenzylacetic acid;NSC-34508;AKOS000201116;2-amino-2-benzyl-3-phenylpropanoicacid;NCGC00327843-01;CS-0374553;EN300-144731;AB01322489-02

Chemical Property of 2-Amino-2-benzyl-3-phenylpropanoic acid

Chemical Property:

• Vapor Pressure: 3.09E-07mmHg at 25°C
• Boiling Point: 403.5°Cat760mmHg
• Flash Point: 197.9°C
• Density: 1.191g/cm³
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 255.125928785
• Heavy Atom Count: 19
• Complexity: 271

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(CC2=CC=CC=C2)(C(=O)O)N

Technology Process of 2-Amino-2-benzyl-3-phenylpropanoic acid

There total 32 articles about 2-Amino-2-benzyl-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-acetyl-α,α-dibenzylglycine (94164-89-3) → 2-amino-2-benzyl-3-phenylpropanoic acid (6278-96-2)

Guidance literature:

With hydrogen bromide; for 2h; Heating;

DOI:10.1039/b212473b

Reference yield: 91.0%

N-(tert-butoxycarbonyl)-α-benzylphenylalanine (146648-27-3) → 2-amino-2-benzyl-3-phenylpropanoic acid (6278-96-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 2h; Ambient temperature;

Reference yield: 88.0%

ethyl 2-amino-2-benzyl-3-phenylpropanoate (93949-90-7) → 2-amino-2-benzyl-3-phenylpropanoic acid (6278-96-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 24h; Heating;

DOI:10.1021/jo015809o

upstream raw materials:

2,2-dibenzyl-acetoacetic acid ethyl ester

2-acetylamino-2-benzyl-3-phenyl-propionic acid ethyl ester

5,5-di-benzyl-hydantoin

N,α-Dibenzyl-phenylalanin

Downstream raw materials:

(4,4-dibenzyl-5-oxo-4,5-dihydro-oxazol-2-ylmethyl)-carbamic acid benzyl ester

N^α-(9-fluorenylmethoxycarbonyl)-2,2-dibenzylglycine

2-benzyl-2-[(N-benzyloxycarbonyl-glycyl)-amino]-3-phenyl-propionic acid