3-Isoxazolecarboxamide, N-(2-(hydroxymethyl)-6-methylphenyl)-5-methyl-

Base Information

Chemical Name:3-Isoxazolecarboxamide, N-(2-(hydroxymethyl)-6-methylphenyl)-5-methyl-
CAS No.:145440-96-6
Molecular Formula:C13H14 N2 O3
Molecular Weight:246.2619
Hs Code.:
DSSTox Substance ID:DTXSID20163025
Nikkaji Number:J517.265I
Wikidata:Q83031862
Mol file:145440-96-6.mol

Synonyms:BRN 5818991;3-Isoxazolecarboxamide, N-(2-(hydroxymethyl)-6-methylphenyl)-5-methyl-;N-(2-(Hydroxymethyl)-6-methylphenyl)-5-methyl-3-isoxazolecarboxamide;N-(2-Methyl-6-hydroxymethylphenyl)-5-methyl-3-isoxazolecarboxamide;145440-96-6;DTXSID20163025;LS-86562;5-Methyl-N-[2-methyl-6-(hydroxymethyl)phenyl]isoxazole-3-carboxamide

Suppliers and Price of 3-Isoxazolecarboxamide, N-(2-(hydroxymethyl)-6-methylphenyl)-5-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-Isoxazolecarboxamide, N-(2-(hydroxymethyl)-6-methylphenyl)-5-methyl-

Chemical Property:

Vapor Pressure:4.73E-06mmHg at 25°C
Boiling Point:367.6°Cat760mmHg
Flash Point:176.1°C
Density:1.291g/cm³
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:246.10044231
Heavy Atom Count:18
Complexity:298

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)CO)NC(=O)C2=NOC(=C2)C

Technology Process of 3-Isoxazolecarboxamide, N-(2-(hydroxymethyl)-6-methylphenyl)-5-methyl-

There total 3 articles about 3-Isoxazolecarboxamide, N-(2-(hydroxymethyl)-6-methylphenyl)-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 145440-92-2
3-Methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-benzoic acid ethyl ester

: 145440-96-6
N-(2-methyl-6-hydroxymethylphenyl)-5-methyl-3-isoxazolecarboxamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/0223-5234(92)90137-P

Reference yield:

: 39499-34-8
5-methyl-3-isoxazolyl chloride

: 145440-96-6
N-(2-methyl-6-hydroxymethylphenyl)-5-methyl-3-isoxazolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / toluene / Ambient temperature

2: 87 percent / LiAlH₄ / tetrahydrofuran / 0 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1016/0223-5234(92)90137-P

Reference yield:

: 64818-79-7
2-ethoxycarbonyl-6-methyl-aniline

: 145440-96-6
N-(2-methyl-6-hydroxymethylphenyl)-5-methyl-3-isoxazolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / toluene / Ambient temperature

2: 87 percent / LiAlH₄ / tetrahydrofuran / 0 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1016/0223-5234(92)90137-P