Butanoic acid, 3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2- a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester, (3S)-

Base Information

Chemical Name:Butanoic acid, 3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2- a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester, (3S)-
CAS No.:192755-43-4
Molecular Formula:C25H32N4O7
Molecular Weight:500.552
Hs Code.:

Butanoic acid,
3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2-
a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester,
(3S)-

Synonyms:

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Chemical Property of Butanoic acid, 3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2- a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester, (3S)-

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Safty Information:

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Technology Process of Butanoic acid, 3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2- a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester, (3S)-

There total 23 articles about Butanoic acid, 3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2- a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 234752-71-7
3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-N-methoxy-N-methyl-succinamic acid tert-butyl ester

: 192755-43-4
3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-4-oxo-butyric acid tert-butyl ester

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at -40 ℃;
DOI:10.1016/S0960-894X(99)00236-X

Reference yield:

: 4509-90-4
5-bromovaleroyl chloride

: 192755-43-4
3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-4-oxo-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 15 steps

1: 1.) nBuLi / 1.) THF, -78 deg C, 2.) THF

2: 1.) LDA, 2.) Bu₄NI, DMPU / 1.) THF, -78 deg C, 2.) CH₂Cl₂

3: 98 percent / LiOH / tetrahydrofuran; H₂O

4: 100 percent / CH₂Cl₂

5: 98 percent / aq. NaOH / toluene

6: 85 percent / H₂SO₄ / dioxane

7: aq. NaHCO₃

8: 97 percent / H₂ / Pd/C / methanol

9: PCl₅ / tetrahydrofuran

10: N-ethylmorpholine / tetrahydrofuran

11: 98 percent / NH₂MH₂*H₂O / ethanol

12: 97 percent / aq. NaHCO₃

13: 94 percent / TFA / CH₂Cl₂

14: 84 percent / BOP, HOBt, i-Pr₂NEt / CH₂Cl₂

15: 51 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / -40 °C

With N-ethylmorpholine;; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; phosphorus pentachloride; sulfuric acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; hydrazine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; toluene;
DOI:10.1016/S0960-894X(99)00236-X

Reference yield:

: 1676-73-9,25014-27-1
L-glutamic acid γ-benzyl ester

: 192755-43-4
3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-4-oxo-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 98 percent / TEA / tetrahydrofuran / Heating

2: PCl₅ / CH₂Cl₂

3: aq. NaHCO₃

4: 97 percent / H₂ / Pd/C / methanol

5: PCl₅ / tetrahydrofuran

6: N-ethylmorpholine / tetrahydrofuran

7: 98 percent / NH₂MH₂*H₂O / ethanol

8: 97 percent / aq. NaHCO₃

9: 94 percent / TFA / CH₂Cl₂

10: 84 percent / BOP, HOBt, i-Pr₂NEt / CH₂Cl₂

11: 51 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / -40 °C

With N-ethylmorpholine;; lithium aluminium tetrahydride; TEA; phosphorus pentachloride; hydrogen; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; hydrazine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(99)00236-X