Pyridine, 4-[2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-[4-[2,2,2-trifluoro-1-(trifluoro methyl)-1-[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]ethyl]-, (R)-

Base Information

Chemical Name:Pyridine, 4-[2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-[4-[2,2,2-trifluoro-1-(trifluoro methyl)-1-[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]ethyl]-, (R)-
CAS No.:192767-05-8
Molecular Formula:C34H41F6NO4Si
Molecular Weight:669.78
Hs Code.:

Pyridine,
4-[2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-[4-[2,2,2-trifluoro-1-(trifluoro
methyl)-1-[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]ethyl]-, (R)-

Synonyms:

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Chemical Property of Pyridine, 4-[2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-[4-[2,2,2-trifluoro-1-(trifluoro methyl)-1-[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]ethyl]-, (R)-

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Technology Process of Pyridine, 4-[2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-[4-[2,2,2-trifluoro-1-(trifluoro methyl)-1-[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]ethyl]-, (R)-

There total 7 articles about Pyridine, 4-[2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-[4-[2,2,2-trifluoro-1-(trifluoro methyl)-1-[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]ethyl]-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 192767-05-8
(R)-4-{2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-[4-(2-(2-(trimethylsilyl)ethoxymethoxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl]ethyl}pyridine

Guidance literature:

Reference yield:

: 3-(3-cyclopentyloxy-4-methoxy-phenyl)-2-pyridin-4-yl-3-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-thiopropionic acid S-propyl ester

: 192767-05-8
(R)-4-{2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-[4-(2-(2-(trimethylsilyl)ethoxymethoxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl]ethyl}pyridine

Guidance literature:: With lithium hydroxide; In tetrahydrofuran;
DOI:10.1016/S0960-894X(02)00349-9

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 192767-05-8
(R)-4-{2-(3-Cyclopentyloxy-4-methoxyphenyl)-2-[4-(2-(2-(trimethylsilyl)ethoxymethoxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl]ethyl}pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / diethyl ether / -78 °C

1.2: diethyl ether

2.1: i-Pr₂NEt / CH₂Cl₂

3.1: Mg / tetrahydrofuran

3.2: 58 percent / tetrahydrofuran / 0 °C

4.1: tetrahydrofuran / 0 - 20 °C

5.1: aq. LiOH / tetrahydrofuran

With lithium hydroxide; n-butyllithium; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(02)00349-9