4-Pyridineacetic acid, a-[[3,4-bis(difluoromethoxy)phenyl][4-[2,2,2-trifluoro-1-(trifluoromethyl)-1 -[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]methyl]-, ethyl ester

Base Information

Chemical Name:4-Pyridineacetic acid, a-[[3,4-bis(difluoromethoxy)phenyl][4-[2,2,2-trifluoro-1-(trifluoromethyl)-1 -[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]methyl]-, ethyl ester
CAS No.:192767-14-9
Molecular Formula:C33H35F10NO6Si
Molecular Weight:759.714
Hs Code.:

4-Pyridineacetic acid,
a-[[3,4-bis(difluoromethoxy)phenyl][4-[2,2,2-trifluoro-1-(trifluoromethyl)-1
-[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]methyl]-, ethyl ester

Synonyms:

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Chemical Property of 4-Pyridineacetic acid, a-[[3,4-bis(difluoromethoxy)phenyl][4-[2,2,2-trifluoro-1-(trifluoromethyl)-1 -[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]methyl]-, ethyl ester

Chemical Property:

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Technology Process of 4-Pyridineacetic acid, a-[[3,4-bis(difluoromethoxy)phenyl][4-[2,2,2-trifluoro-1-(trifluoromethyl)-1 -[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]methyl]-, ethyl ester

There total 8 articles about 4-Pyridineacetic acid, a-[[3,4-bis(difluoromethoxy)phenyl][4-[2,2,2-trifluoro-1-(trifluoromethyl)-1 -[[2-(trimethylsilyl)ethoxy]methoxy]ethyl]phenyl]methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54401-85-3
pyridin-4-yl-acetic acid ethyl ester

: 192767-13-8
[2-(1-{4-[(3,4-bis-difluoromethoxy-phenyl)-chloro-methyl]-phenyl}-2,2,2-trifluoro-1-trifluoromethyl-ethoxymethoxy)-ethyl]-trimethyl-silane

: 192767-14-9
3-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-3-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-propionic acid ethyl ester

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0960-894X(02)00190-7

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 192767-14-9
3-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-3-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: BuLi / diethyl ether / 0.5 h / -78 °C

1.2: 75 percent / diethyl ether / 2 h / -50 °C

2.1: 95 percent / iPr₂NEt / CH₂Cl₂ / 18 h / 20 °C

3.1: Mg / tetrahydrofuran / 1.5 h / Heating

3.2: tetrahydrofuran / 1.5 h / -78 °C

4.1: SOCl₂; pyridine / toluene / 0.5 h / 20 °C

5.1: KHMDS; HMPA / tetrahydrofuran / 3 h / 20 °C

5.2: HMPA / tetrahydrofuran / 3 h / 20 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; thionyl chloride; potassium hexamethylsilazane; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 3.2: Grignard reaction;
DOI:10.1016/S0960-894X(02)00615-7

Reference yield:

: 2402-72-4
2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 192767-14-9
3-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-3-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / iPr₂NEt / CH₂Cl₂ / 18 h / 20 °C

2.1: Mg / tetrahydrofuran / 1.5 h / Heating

2.2: tetrahydrofuran / 1.5 h / -78 °C

3.1: SOCl₂; pyridine / toluene / 0.5 h / 20 °C

4.1: KHMDS; HMPA / tetrahydrofuran / 3 h / 20 °C

4.2: HMPA / tetrahydrofuran / 3 h / 20 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; potassium hexamethylsilazane; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene; 2.2: Grignard reaction;
DOI:10.1016/S0960-894X(02)00615-7