Benzoic acid, 4-[4-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[(triphenylmethyl) thio]propyl]amino]phenoxy]-, (R)-

Base Information

• Chemical Name: Benzoic acid, 4-[4-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[(triphenylmethyl) thio]propyl]amino]phenoxy]-, (R)-
• CAS No.: 192768-32-4
• Molecular Formula: C₄₀H₃₈N₂O₆S
• Molecular Weight: 674.818
• Mol file: 192768-32-4.mol

Synonyms:

Chemical Property of Benzoic acid, 4-[4-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[(triphenylmethyl) thio]propyl]amino]phenoxy]-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-[4-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[(triphenylmethyl) thio]propyl]amino]phenoxy]-, (R)-

There total 5 articles about Benzoic acid, 4-[4-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[(triphenylmethyl) thio]propyl]amino]phenoxy]-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-phenoxy]-benzoic acid methyl ester (192768-31-3) → 4-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-phenoxy]-benzoic acid (192768-32-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0960-894X(97)00225-4

Reference yield:

methyl 4-(4-nitrophenoxy)benzoate (21120-78-5) → 4-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-phenoxy]-benzoic acid (192768-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Fe, HOAc / methanol / Heating

2: EDC, HOBt / dimethylformamide

3: aq. NaOH / tetrahydrofuran / 0 °C

With sodium hydroxide; iron; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(97)00225-4

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-phenoxy]-benzoic acid (192768-32-4)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 80 °C

2: Fe, HOAc / methanol / Heating

3: EDC, HOBt / dimethylformamide

4: aq. NaOH / tetrahydrofuran / 0 °C

With sodium hydroxide; iron; potassium carbonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(97)00225-4

upstream raw materials:

4-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-phenoxy]-benzoic acid methyl ester

methyl 4-(4-nitrophenoxy)benzoate

methyl 4-hydroxylbenzoate

4-Fluoronitrobenzene