n-(1,3-Benzodioxol-5-ylmethyl)-2,2,2-trifluoro-n-[2-(4-hydroxyphenyl)ethyl]acetamide

Base Information

Chemical Name:n-(1,3-Benzodioxol-5-ylmethyl)-2,2,2-trifluoro-n-[2-(4-hydroxyphenyl)ethyl]acetamide
CAS No.:40135-88-4
Molecular Formula:C18H16 F3 N O4
Molecular Weight:367.325
Hs Code.:
NSC Number:159938
DSSTox Substance ID:DTXSID50303679
Nikkaji Number:J2.052.695E
Wikidata:Q82049082
Mol file:40135-88-4.mol

Synonyms:n-(1,3-benzodioxol-5-ylmethyl)-2,2,2-trifluoro-n-[2-(4-hydroxyphenyl)ethyl]acetamide;40135-88-4;NSC159938;SCHEMBL19529617;DTXSID50303679;FVOHWJUBZNYSHR-UHFFFAOYSA-N;AKOS004907110;NSC-159938

Suppliers and Price of n-(1,3-Benzodioxol-5-ylmethyl)-2,2,2-trifluoro-n-[2-(4-hydroxyphenyl)ethyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of n-(1,3-Benzodioxol-5-ylmethyl)-2,2,2-trifluoro-n-[2-(4-hydroxyphenyl)ethyl]acetamide

Chemical Property:

Vapor Pressure:2.31E-12mmHg at 25°C
Boiling Point:542.1°Cat760mmHg
Flash Point:281.6°C
Density:1.397g/cm³
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:367.10314248
Heavy Atom Count:26
Complexity:480

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1OC2=C(O1)C=C(C=C2)CN(CCC3=CC=C(C=C3)O)C(=O)C(F)(F)F

Technology Process of n-(1,3-Benzodioxol-5-ylmethyl)-2,2,2-trifluoro-n-[2-(4-hydroxyphenyl)ethyl]acetamide

There total 5 articles about n-(1,3-Benzodioxol-5-ylmethyl)-2,2,2-trifluoro-n-[2-(4-hydroxyphenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 500731-43-1
4-(2-piperonylamino-ethyl)-phenol

: 407-25-0
trifluoroacetic anhydride

: 40135-88-4
N-trifluoroacetyl-N-3',4'-methylenedioxyphenylmethyl-[2-(4-hydroxyphenyl)]ethylamine

Guidance literature:: With pyridine; at 0 ℃; for 2h;
DOI:10.1016/j.tet.2004.03.087

Reference yield:

: 51-67-2
tyrosamine

: 40135-88-4
N-trifluoroacetyl-N-3',4'-methylenedioxyphenylmethyl-[2-(4-hydroxyphenyl)]ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 6 h / 20 °C

1.2: NaBH₄ / methanol / 24 h

2.1: 3.0 g / pyridine / 2 h / 0 °C

With pyridine; In methanol;
DOI:10.1016/j.tet.2004.03.087

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 40135-88-4
N-trifluoroacetyl-N-3',4'-methylenedioxyphenylmethyl-[2-(4-hydroxyphenyl)]ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 6 h / 20 °C

1.2: NaBH₄ / methanol / 24 h

2.1: 3.0 g / pyridine / 2 h / 0 °C

With pyridine; In methanol;
DOI:10.1016/j.tet.2004.03.087