4-(4-Methylbenzyl)-piperidin-4-ol

Base Information

Chemical Name:4-(4-Methylbenzyl)-piperidin-4-ol
CAS No.:192990-05-9
Molecular Formula:C13H19NO
Molecular Weight:205.3
Hs Code.:
DSSTox Substance ID:DTXSID90441403
Wikidata:Q82258165
Mol file:192990-05-9.mol

Synonyms:4-(4-methylbenzyl)-piperidin-4-ol;192990-05-9;4-(4-methylbenzyl)piperidin-4-ol;4-[(4-methylphenyl)methyl]piperidin-4-ol;SCHEMBL2989469;DTXSID90441403;DGNFSJPAWJLVOH-UHFFFAOYSA-N;4-(4-methyl-benzyl)-piperidin-4-ol;AKOS012082143;4-hydroxy-4-(4-methyl-benzyl)-piperidine;CS-0353489;EN300-189872

Suppliers and Price of 4-(4-Methylbenzyl)-piperidin-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-(4-Methylbenzyl)-piperidin-4-ol

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:205.146664230
Heavy Atom Count:15
Complexity:191

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)CC2(CCNCC2)O

Technology Process of 4-(4-Methylbenzyl)-piperidin-4-ol

There total 8 articles about 4-(4-Methylbenzyl)-piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 4-hydroxy-4-(4-methyl-benzyl)-piperidin-1-carboxylic acid ethylester

: 192990-05-9
4-hydroxy-4-(4-methyl-benzyl)-piperidine

Guidance literature:: With sodium hydroxide; In ethanol; water;

Reference yield:

: 193357-89-0
1-benzyl-4-hydroxy-4-(4-methylbenzyl)piperidine

: 192990-05-9
4-hydroxy-4-(4-methyl-benzyl)-piperidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 2585.74 Torr;
DOI:10.1021/jm990246i

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 192990-05-9
4-hydroxy-4-(4-methyl-benzyl)-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Mg, 1,2-dibromoethane / 1.) THF, RT, 30 min, 2.) THF, from -40 deg C to RT, overnight

2: H₂, AcOH / 10 percent Pd/C / ethanol

With hydrogen; magnesium; acetic acid; ethylene dibromide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm990148x