2-((2-methoxy-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl 4-(2-(2-(9H-fluoren-9-yl)acetamido)ethyl)benzoate

Base Information

Chemical Name:2-((2-methoxy-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl 4-(2-(2-(9H-fluoren-9-yl)acetamido)ethyl)benzoate
CAS No.:159978-02-6
Molecular Formula:C₃₆H₃₅F₃N₂O₄
Molecular Weight:616.68
Hs Code.:
UNII:5DLU91775Q,34J8SAF62N,WHJ73DP4AM
DSSTox Substance ID:DTXSID70936206
Nikkaji Number:J675.492I
Wikidata:Q27261881

Synonyms:3-(2-(2-(4-(2-(alpha-fluorenylacetylaminoethyl)benzoyloxy)ethylamino)-1-methoxylethyl))trifluoromethylbenzene;S 15261;S-15261;S15261

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((2-methoxy-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl 4-(2-(2-(9H-fluoren-9-yl)acetamido)ethyl)benzoate

Chemical Property:

Vapor Pressure:9.43E-23mmHg at 25°C
Boiling Point:756.1°Cat760mmHg
Flash Point:411.1°C
Density:1.234g/cm³
XLogP3:6.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:14
Exact Mass:616.25489209
Heavy Atom Count:45
Complexity:918

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(CNCCOC(=O)C1=CC=C(C=C1)CCNC(=O)CC2C3=CC=CC=C3C4=CC=CC=C24)C5=CC(=CC=C5)C(F)(F)F

Technology Process of 2-((2-methoxy-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl 4-(2-(2-(9H-fluoren-9-yl)acetamido)ethyl)benzoate

There total 7 articles about 2-((2-methoxy-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl 4-(2-(2-(9H-fluoren-9-yl)acetamido)ethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027718-49-5
4-[2-(2-9H-Fluoren-9-yl-acetylamino)-ethyl]-benzoic acid 2-{benzyl-[2-methoxy-2-(3-trifluoromethyl-phenyl)-ethyl]-amino}-ethyl ester

: 159978-02-6,212752-68-6,212752-69-7
4-[2-(2-9H-Fluoren-9-yl-acetylamino)-ethyl]-benzoic acid 2-[2-methoxy-2-(3-trifluoromethyl-phenyl)-ethylamino]-ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In isopropyl alcohol; at 50 ℃; under 4654.3 Torr;

Reference yield:

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 159978-02-6,212752-68-6,212752-69-7
4-[2-(2-9H-Fluoren-9-yl-acetylamino)-ethyl]-benzoic acid 2-[2-methoxy-2-(3-trifluoromethyl-phenyl)-ethylamino]-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / MgI₂ / diethyl ether / 2 h / Heating

2: xylene / 6 h / Heating

3: 1.) NaOH; 2.) K₂CO₃ / 48 h / Heating; 1.) ether; 2.) EtOH

4: lithium aluminium hydride / tetrahydrofuran / 6 h / 45 °C

5: POCl₃ / toluene / 1 h / Heating

6: K₂CO₃ / dimethylformamide / 2 h / 90 °C

7: H₂ / 5percent Pd/C / propan-2-ol / 50 °C / 4654.3 Torr

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; magnesium iodide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; isopropyl alcohol; toluene; xylene;

Reference yield:

: 3289-05-2
3-trifluoromethyl-1-(2-bromo-1-methoxyethyl)benzene

: 159978-02-6,212752-68-6,212752-69-7
4-[2-(2-9H-Fluoren-9-yl-acetylamino)-ethyl]-benzoic acid 2-[2-methoxy-2-(3-trifluoromethyl-phenyl)-ethylamino]-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: xylene / 6 h / Heating

2: 1.) NaOH; 2.) K₂CO₃ / 48 h / Heating; 1.) ether; 2.) EtOH

3: lithium aluminium hydride / tetrahydrofuran / 6 h / 45 °C

4: POCl₃ / toluene / 1 h / Heating

5: K₂CO₃ / dimethylformamide / 2 h / 90 °C

6: H₂ / 5percent Pd/C / propan-2-ol / 50 °C / 4654.3 Torr

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol; toluene; xylene;