1H-Indazol-7-amine

Base Information

Chemical Name:1H-Indazol-7-amine
CAS No.:21443-96-9
Molecular Formula:C7H7N3
Molecular Weight:133.153
Hs Code.:29339900
European Community (EC) Number:244-391-8
NSC Number:170661
DSSTox Substance ID:DTXSID10175718
Nikkaji Number:J41.000D
Wikidata:Q27451589
ChEMBL ID:CHEMBL463676
Mol file:21443-96-9.mol

Synonyms:1H-Indazol-7-amine;7-Amino-1H-indazole;21443-96-9;2H-Indazol-7-amine;7-Aminoindazole;918903-47-6;1H-Indazol-7-ylamine;CHEMBL463676;EINECS 244-391-8;MFCD00022790;NSC 170661;BRN 0003640;AI3-52441;NSC44675;10L;4b6e;1H-indazol-7-amine, 1;SCHEMBL655480;7-Amino-1H-indazole, 97%;SCHEMBL13724990;DTXSID10175718;AMY13376;BCP27106;BDBM50271275;NSC170661;STK505485;AKOS001438952;AC-3120;NSC-170661;PB12978;LS-81358;SY003896;A4620;CS-0008181;FT-0638121;EN300-28544;3P-091;4-25-00-02526 (Beilstein Handbook Reference);W-206629;Q27451589;Z235348069

Suppliers and Price of 1H-Indazol-7-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1H-Indazol-7-amine
250mg
$ 55.00

SynQuest Laboratories
7-Amino-1H-indazole 95%
250 mg
$ 20.00

SynQuest Laboratories
7-Amino-1H-indazole 95%
1 g
$ 37.00

Sigma-Aldrich
7-Amino-1H-indazole 97%
1g
$ 60.00

Matrix Scientific
1H-Indazol-7-amine >95%
500mg
$ 25.00

Matrix Scientific
1H-Indazol-7-amine dihydrochloride
500mg
$ 315.00

Frontier Specialty Chemicals
7-Amino-1H-indazole 97%
5g
$ 284.00

Frontier Specialty Chemicals
7-Amino-1H-indazole 97%
1g
$ 71.00

Crysdot
7-Amino-1H-indazole 97%
10g
$ 165.00

Chemenu
1H-indazol-7-amine 97%
25g
$ 330.00

Total 52 raw suppliers

Chemical Property of 1H-Indazol-7-amine

Chemical Property:

Vapor Pressure:7.16E-06mmHg at 25°C
Melting Point:156-159 °C
Refractive Index:1.78
Boiling Point:376.6 °C at 760 mmHg
PKA:14.89±0.40(Predicted)
Flash Point:209.5 °C
PSA：54.70000
Density:1.367 g/cm³
LogP:1.72630
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:133.063997236
Heavy Atom Count:10
Complexity:126

Purity/Quality:

99%, ^*data from raw suppliers

1H-Indazol-7-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,Xn
Statements: 34-36/37/38-22
Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC2=C(C(=C1)N)NN=C2
General Description 1H-Indazol-7-amine is a versatile heterocyclic scaffold that serves as a key intermediate in the synthesis of diverse indazole derivatives, including those with potential biological activity. It exhibits reactivity as a bidentate nucleophile, enabling the formation of complex heterocyclic systems such as halopyrazolo[4,5-h]quinolines and halopyrazolo[1,5,4-ef][1,5]benzodiazepines. Additionally, its derivatives have been explored in medicinal chemistry, particularly in the development of bromodomain inhibitors, demonstrating the structural significance of the indazole core in drug discovery. 1H-Indazol-7-amine's solid-state properties, including hydrogen bonding and molecular interactions, have been characterized through crystallographic and computational studies, highlighting its potential in material and pharmaceutical applications.

Technology Process of 1H-Indazol-7-amine

There total 7 articles about 1H-Indazol-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2942-42-9
7-Nitroindazole

: 21443-96-9
1H-indazol-7-amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm010330+

Reference yield: 61.0%

: 119-26-6
(2,4-dinitro-phenyl)-hydrazine

: 4-butoxycarbonylmethylidene-3,7-dihydro-6-methylpyrazolo[1,5,4-ef][1,5]benzodiazepine

: 21443-96-9
1H-indazol-7-amine

: 5-butoxycarbonylmethylene-4H-3-methyl-1-(2,4-dinitrophenyl)pyrazole

Guidance literature:: In butan-1-ol; for 24h; Heating;
DOI:10.3987/com-00-8869

Reference yield:

: 570-24-1
2-Methyl-6-nitroaniline

: 21443-96-9
1H-indazol-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / aq. NaNO₂; glacial acetic acid / 0.33 h

2: 75 percent / NH₄(+)HCOO(-); H₂ / Pd/C / ethanol

With hydrogen; acetic acid; sodium nitrite; palladium on activated charcoal; In ethanol;
DOI:10.1055/s-2007-977416