1-Boc-2-Methylpiperidine-4-carboxylic Acid

Base Information

• Chemical Name: 1-Boc-2-Methylpiperidine-4-carboxylic Acid
• CAS No.: 193085-98-2
• Molecular Formula: C12H21NO4
• Molecular Weight: 243.29900
• Mol file: 193085-98-2.mol

Synonyms:1,4-Piperidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) ester;1-Boc-2-methylpiperidine-4-carboxylic Acid;

Chemical Property of 1-Boc-2-Methylpiperidine-4-carboxylic Acid

Chemical Property:

• PSA: 66.84000
• LogP: 2.04450
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-2-Methyl-1,4-piperidinedicarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Boc-2-Methyl-1,4-piperidinedicarboxylic Acid is a boc protected 2-methyl-1,4-piperidinedicarboxylic Acid which is used in the preparation of indazole and pyrrolopyridine derivatives. These derivatives are useful in the treatment of Alzheimer-type dementia as 5-HT4 receptor agonists.

Technology Process of 1-Boc-2-Methylpiperidine-4-carboxylic Acid

There total 40 articles about 1-Boc-2-Methylpiperidine-4-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C12H21NO3 (416852-38-5) → 1-[(tert-butoxy)carbonyl]-2-methylpiperidine-4-carboxylic acid (1250959-07-9,193085-98-2,1932555-95-7)

Guidance literature:

With sodium chlorite; potassium phosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 23 ℃; for 2h;

Reference yield: 71.0%

1-(tert-butyl) 4-methyl 2-methylpiperidine-1,4-dicarboxylate (1415740-83-8) → 1-[(tert-butoxy)carbonyl]-2-methylpiperidine-4-carboxylic acid (1250959-07-9,193085-98-2,1932555-95-7)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 - 40 ℃; for 1h;

Reference yield:

2-methylisonicotinic acid (4021-11-8) → 1-[(tert-butoxy)carbonyl]-2-methylpiperidine-4-carboxylic acid (1250959-07-9,193085-98-2,1932555-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 20 h / Reflux

2.1: hydrogen / platinum(IV) oxide / methanol / 96 h / 20 °C / 2327.23 Torr

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

3.2: pH 2

With sulfuric acid; water; hydrogen; sodium hydroxide; platinum(IV) oxide; In tetrahydrofuran; methanol;

upstream raw materials:

C₁₂H₂₁NO₃

di-tert-butyl dicarbonate

C₇H₁₃NO₂

methyl 2-methylisonicotinate

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