Technology Process of Aerobactin
There total 6 articles about Aerobactin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C44H60N4O15;
With
trifluoroacetic acid;
In
dichloromethane;
for 1h;
With
sodium hydroxide;
In
tetrahydrofuran; dichloromethane;
for 0.666667h;
DOI:10.1039/c7cc05197b
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / 0.5 h / 0 °C
1.2: 2 h / 0 °C
2.1: dichloromethane / 6 h / 0 - 20 °C
3.1: pyridine / dichloromethane / 4 h / 50 °C
4.1: hydrogen bromide / dichloromethane; acetic acid / 0.67 h
5.1: sodium hydrogencarbonate / tetrahydrofuran / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 1 h
6.2: 0.67 h
With
pyridine; thionyl chloride; hydrogen bromide; sodium hydrogencarbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1039/c7cc05197b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dichloromethane / 6 h / 0 - 20 °C
2.1: pyridine / dichloromethane / 4 h / 50 °C
3.1: hydrogen bromide / dichloromethane; acetic acid / 0.67 h
4.1: sodium hydrogencarbonate / tetrahydrofuran / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 1 h
5.2: 0.67 h
With
pyridine; hydrogen bromide; sodium hydrogencarbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1039/c7cc05197b
