2,3,4,10-Tetrahydro-2,2-dimethyl-5H-pyrano[2,3-b]quinolin-5-one

Base Information

• Chemical Name: 2,3,4,10-Tetrahydro-2,2-dimethyl-5H-pyrano[2,3-b]quinolin-5-one
• CAS No.: 6431-83-0
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.279
• Hs Code.: 2934999090
• Mol file: 6431-83-0.mol

Synonyms:Haplofoline;Khaplofoline

Chemical Property of 2,3,4,10-Tetrahydro-2,2-dimethyl-5H-pyrano[2,3-b]quinolin-5-one

Chemical Property:

• Melting Point: 272-4°C
• PSA: 42.09000
• LogP: 2.63170

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Russian workers have described this pyranoquinoline alkaloid which occurs in Hapiophyllum foliosum Vved. The base crystallizes from MeOH as colourless rods and forms a series of crystalline salts and derivative, e.g. hydrochloride, m.p. 78-80°C; sulphate, m.p. 196-7°C; the bromo derivative, m.p. 186-8°C; the N-acetyl compound, m.p. 155-6°C and the N-methyl derivative with m.p. 121°C.

Technology Process of 2,3,4,10-Tetrahydro-2,2-dimethyl-5H-pyrano[2,3-b]quinolin-5-one

There total 28 articles about 2,3,4,10-Tetrahydro-2,2-dimethyl-5H-pyrano[2,3-b]quinolin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3, 4-dihydro-2,2-dimethyl-5-methoxy-2H-pyrano-[2,3-b]quinoline (42522-05-4) → 2,2-dimethyl-2,3,4,10-tetrahydro-pyrano[2,3-b]quinolin-5-one (6431-83-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 30h; Heating;

DOI:10.1021/np970005i

Reference yield: 96.0%

10-Methoxy-2,2-dimethyl-3,4,9,10-tetrahydro-2H-1-oxa-9-aza-anthracene → 2,2-dimethyl-2,3,4,10-tetrahydro-pyrano[2,3-b]quinolin-5-one (6431-83-0)

Guidance literature:

With hydrogenchloride; In ethanol; Heating;

DOI:10.1016/S0040-4039(00)86996-8

Reference yield: 90.0%

5-oxo-2,2-dimethyl-2H-pyrano<2,3-b>quinoline (143704-18-1) → 2,2-dimethyl-2,3,4,10-tetrahydro-pyrano[2,3-b]quinolin-5-one (6431-83-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 3h;

upstream raw materials:

5-isopropyl-2-oxo-tetrahydro-furan-3-carboxylic acid anilide

3,3-bis(γ,γ-dimethylallyl)-2.4-dioxo-1,2,3,4-tetrahydroquinoline

5-oxo-2,2-dimethyl-2H-pyrano<2,3-b>quinoline

1-(1-Hydroxy-1-methyl-ethyl)-8b-methoxy-2,2a,4,8b-tetrahydro-1H-cyclobuta[c]quinolin-3-one

Downstream raw materials:

flindersine

N-Methyl-Khaplofolin