3-[2-(4-Aminophenyl)ethyl]-8-cyclopentyl-3,7-dihydro-1-propyl-1H-purine-2,6-dione

Base Information

Chemical Name:3-[2-(4-Aminophenyl)ethyl]-8-cyclopentyl-3,7-dihydro-1-propyl-1H-purine-2,6-dione
CAS No.:116370-30-0
Molecular Formula:C21H27 N5 O2
Molecular Weight:381.47
Hs Code.:
Mol file:116370-30-0.mol

Synonyms:1H-Purine-2,6-dione,3-[2-(4-aminophenyl)ethyl]-8-cyclopentyl-3,7-dihydro-1-propyl- (9CI); BW-A 844U

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[2-(4-Aminophenyl)ethyl]-8-cyclopentyl-3,7-dihydro-1-propyl-1H-purine-2,6-dione

Chemical Property:

Boiling Point:671.6±65.0 °C(Predicted)
PKA:8.91±0.70(Predicted)
PSA：98.70000
Density:1.267±0.06 g/cm3(Predicted)
LogP:3.36000

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-[2-(4-Aminophenyl)ethyl]-8-cyclopentyl-3,7-dihydro-1-propyl-1H-purine-2,6-dione

There total 9 articles about 3-[2-(4-Aminophenyl)ethyl]-8-cyclopentyl-3,7-dihydro-1-propyl-1H-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24954-67-4
2-(p-nitrophenyl)ethylamine

: 116370-30-0
[125I]-BW-A 844U

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / toluene / 2 h / Ambient temperature

2: 20 percent / acetic anhydride / 2 h / 75 °C

3: 90 percent / 1N aq. NaOH / 0.5 h / 75 °C

4: 87 percent / H₂ / 10percent Pd/C / 8 h

5: 98 percent / NaHCO₃ / tetrahydrofuran; H₂O; toluene / 0.5 h

6: 82 percent / NaNO₂, aq. HCl / ethanol / 0.5 h / 30 °C

7: 86 percent / Na₂S₂O₄ / ethanol; H₂O / 0.5 h

8: 1-ethyl-2-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC*HCl) / dioxane; H₂O / 18 h

9: 2N aq. NaOH / tetrahydrofuran / 1 h / Heating

With hydrogenchloride; sodium hydroxide; sodium dithionite; hydrogen; acetic anhydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene;
DOI:10.1021/jm00069a009

Reference yield:

: 149340-93-2
1-(4-nitrophenethyl)-3-propylurea

: 116370-30-0
[125I]-BW-A 844U

Guidance literature:: Multi-step reaction with 8 steps

1: 20 percent / acetic anhydride / 2 h / 75 °C

2: 90 percent / 1N aq. NaOH / 0.5 h / 75 °C

3: 87 percent / H₂ / 10percent Pd/C / 8 h

4: 98 percent / NaHCO₃ / tetrahydrofuran; H₂O; toluene / 0.5 h

5: 82 percent / NaNO₂, aq. HCl / ethanol / 0.5 h / 30 °C

6: 86 percent / Na₂S₂O₄ / ethanol; H₂O / 0.5 h

7: 1-ethyl-2-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC*HCl) / dioxane; H₂O / 18 h

8: 2N aq. NaOH / tetrahydrofuran / 1 h / Heating

With hydrogenchloride; sodium hydroxide; sodium dithionite; hydrogen; acetic anhydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene;
DOI:10.1021/jm00069a009

Reference yield:

: 149340-95-4
6-amino-1-(4-nitrophenethyl)-3-propyluracil

: 116370-30-0
[125I]-BW-A 844U

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / H₂ / 10percent Pd/C / 8 h

2: 98 percent / NaHCO₃ / tetrahydrofuran; H₂O; toluene / 0.5 h

3: 82 percent / NaNO₂, aq. HCl / ethanol / 0.5 h / 30 °C

4: 86 percent / Na₂S₂O₄ / ethanol; H₂O / 0.5 h

5: 1-ethyl-2-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC*HCl) / dioxane; H₂O / 18 h

6: 2N aq. NaOH / tetrahydrofuran / 1 h / Heating

With hydrogenchloride; sodium hydroxide; sodium dithionite; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene;
DOI:10.1021/jm00069a009