5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 2,3,3a,4,6,7-hexahydro-3-oxo-3a-(phenylmethyl)-2-(2,2,2-trifluoroethyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 2,3,3a,4,6,7-hexahydro-3-oxo-3a-(phenylmethyl)-2-(2,2,2-trifluoroethyl)-, 1,1-dimethylethyl ester
• CAS No.: 193274-20-3
• Molecular Formula: C₂₀H₂₄F₃N₃O₃
• Molecular Weight: 411.424
• Mol file: 193274-20-3.mol

Synonyms:

Chemical Property of 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 2,3,3a,4,6,7-hexahydro-3-oxo-3a-(phenylmethyl)-2-(2,2,2-trifluoroethyl)-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 2,3,3a,4,6,7-hexahydro-3-oxo-3a-(phenylmethyl)-2-(2,2,2-trifluoroethyl)-, 1,1-dimethylethyl ester

There total 4 articles about 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 2,3,3a,4,6,7-hexahydro-3-oxo-3a-(phenylmethyl)-2-(2,2,2-trifluoroethyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzyl-4-[(2,2,2-trifluoro-ethyl)-hydrazono]-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester → 3a-benzyl-3-oxo-2-(2,2,2-trifluoro-ethyl)-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (193274-20-3)

Guidance literature:

With acetic acid; In toluene; Heating;

DOI:10.1016/S0960-894X(02)00734-5

Reference yield:

methyl 4-oxonipecotate (108554-34-3,56026-52-9) → 3a-benzyl-3-oxo-2-(2,2,2-trifluoro-ethyl)-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (193274-20-3)

Guidance literature:

Multi-step reaction with 4 steps

1: DMAP / CH₂Cl₂ / 0 °C

2: NaH / dimethylformamide

3: ethanol / Heating

4: HOAc / toluene / Heating

With dmap; sodium hydride; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0960-894X(02)00734-5

Reference yield:

methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate (161491-24-3) → 3a-benzyl-3-oxo-2-(2,2,2-trifluoro-ethyl)-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (193274-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide

2: ethanol / Heating

3: HOAc / toluene / Heating

With sodium hydride; acetic acid; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0960-894X(02)00734-5

upstream raw materials:

methyl 4-oxonipecotate

methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate

3-(R,S)-Benzyl-4-oxo-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

Downstream raw materials:

3a-(R,S)-Benzyl-2-(2,2,2-trifluoro-ethyl)-2,3a,4,5,6,7-hexahydro-pyrazolo[4,3-c]pyridin-3-one