6-Bromo-2-methyl-3-phenylquinazolin-4(3H)-one

Base Information

• Chemical Name: 6-Bromo-2-methyl-3-phenylquinazolin-4(3H)-one
• CAS No.: 4546-25-2
• Molecular Formula: C15H11BrN2O
• Molecular Weight: 315.169
• Hs Code.: 2933990090
• Mol file: 4546-25-2.mol

Synonyms:6-Brom-2-methyl-3-phenyl-3H-chinazolin-4-on;QZH-6;6-bromo-2-methyl-3-phenyl-3H-quinazolin-4-one;

Chemical Property of 6-Bromo-2-methyl-3-phenylquinazolin-4(3H)-one

Chemical Property:

• Vapor Pressure: 2.43E-08mmHg at 25°C
• Melting Point: 186 °C
• Boiling Point: 451.5°Cat760mmHg
• PKA: 1.83±0.70(Predicted)
• Flash Point: 226.8°C
• PSA: 34.89000
• Density: 1.47g/cm³
• LogP: 3.45660

Purity/Quality:

99% ^*data from raw suppliers

6-BROMO-2-METHYL-3-PHENYL-3H-QUINAZOLIN-4-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-2-methyl-3-phenylquinazolin-4(3H)-one

There total 9 articles about 6-Bromo-2-methyl-3-phenylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

acetic acid (64-19-7,77671-22-8) + aniline (62-53-3) + 5-Bromo-2-aminobenzoic acid (5794-88-7) → 6-bromo-2-methyl-3-phenylquinazolin-4(3H)-one (4546-25-2)

Guidance literature:

acetic acid; 5-Bromo-2-aminobenzoic acid; With pyridine; triphenylphosphine; for 4h; Reflux;

aniline; for 12h; Reflux;

DOI:10.1002/jhet.2815

Reference yield: 78.0%

5-bromoisatoic anhydride (4692-98-2) + Triethyl orthoacetate (78-39-7) + aniline (62-53-3) → 6-bromo-2-methyl-3-phenylquinazolin-4(3H)-one (4546-25-2)

Guidance literature:

In neat (no solvent); at 120 ℃; for 5h; Temperature; Green chemistry;

DOI:10.1039/c5ra03888j

Reference yield: 76.0%

6-bromo-3-phenyl-4(3H)-quinazolinone (92103-93-0) → 6-bromo-2-methyl-3-phenylquinazolin-4(3H)-one (4546-25-2)

Guidance literature:

With p-toluenesulfonic acid monohydrate; oxygen; at 110 ℃; Sealed tube; Green chemistry;

DOI:10.1039/d0gc01183e

upstream raw materials:

aniline

5-bromo-N-acetylanthranilic acid

5-bromoisatoic anhydride

Triethyl orthoacetate

Downstream raw materials:

3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-(6-bromo-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylmethyl)-hydrazide

3-(4-dimethylamino-phenyl)-acrylic acid N'-(6-bromo-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylmethyl)-hydrazide

3-(4-methoxy-phenyl)-acrylic acid N'-(6-bromo-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylmethyl)-hydrazide

3-phenyl-acrylic acid N'-(6-bromo-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylmethyl)-hydrazide

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