5-HYDROXY-2-(HYDROXYMETHYL)-4-PYRIDONE

Base Information

• Chemical Name: 5-HYDROXY-2-(HYDROXYMETHYL)-4-PYRIDONE
• CAS No.: 31883-16-6
• Molecular Formula: C6H7 N O3
• Molecular Weight: 141.126
• Hs Code.: 2933399090
• Mol file: 31883-16-6.mol

Synonyms:4(1H)-Pyridone,5-hydroxy-2-(hydroxymethyl)- (6CI,7CI,8CI);2-(Hydroxymethyl)-5-hydroxy-4-pyridone; 5-Hydroxy-2-(hydroxymethyl)-4-pyridone;5-Hydroxy-2-(hydroxymethyl)-g-pyridone; NSC 68955

Chemical Property of 5-HYDROXY-2-(HYDROXYMETHYL)-4-PYRIDONE

Chemical Property:

• Vapor Pressure: 1.58E-06mmHg at 25°C
• Boiling Point: 356.9°C at 760 mmHg
• Flash Point: 169.7°C
• PSA: 73.32000
• Density: 1.453g/cm³
• LogP: -0.42720
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-HYDROXY-2-(HYDROXYMETHYL)-4-PYRIDONE

There total 6 articles about 5-HYDROXY-2-(HYDROXYMETHYL)-4-PYRIDONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

5-benzyloxy-2-hydroxymethyl-1H-pyridin-4-one (59281-14-0) → 6-hydroxymethyl-3-hydroxy-4-pyridinone (31883-16-6)

Guidance literature:

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 8h; under 1551.49 Torr;

DOI:10.1016/j.bmcl.2016.05.006

Reference yield:

5-benzyloxy-2-hydroxymethyl-1H-pyridin-4-one (59281-14-0) → 6-hydroxymethyl-3,4-pyridinediol (736088-02-1,31883-16-6)

Guidance literature:

With sodium hydroxide; hydrogen; 10% palladium on activated carbon; In water; for 4h;

Reference yield:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) → 6-hydroxymethyl-3-hydroxy-4-pyridinone (31883-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 5 h / 100 °C

2: ammonium hydroxide / 16 h / 90 °C / Sealed tube

3: palladium 10% on activated carbon; hydrogen; sodium hydroxide / water / 16 h / 20 °C / Inert atmosphere

With ammonium hydroxide; palladium 10% on activated carbon; hydrogen; sodium hydroxide; In methanol; water;

upstream raw materials:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

5-benzyloxy-2-hydroxymethyl-1H-pyridin-4-one

5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one

Downstream raw materials:

2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde

(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-methanol

2-(4-Bromo-phenylazo)-3-hydroxy-6-hydroxymethyl-1H-pyridin-4-one

2-(3-Chloro-phenylazo)-3-hydroxy-6-hydroxymethyl-1H-pyridin-4-one