Technology Process of (Z)-5-[(3aS,5R,6R,6aS)-5-hydroxy-6-[(E,3S,4S)-3-hydroxy-4-methylnon-1-en-6-ynyl]-1,3a,4,5,6,6a-hexahydropentalen-2-yl]pent-4-enoic acid
There total 7 articles about (Z)-5-[(3aS,5R,6R,6aS)-5-hydroxy-6-[(E,3S,4S)-3-hydroxy-4-methylnon-1-en-6-ynyl]-1,3a,4,5,6,6a-hexahydropentalen-2-yl]pent-4-enoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) t-butoxide / 1.) THF, -78 deg C
2: 100 percent / Bu4N(1+)*F(1-) / tetrahydrofuran
3: SO3, pyridine, triethylamine / dimethylsulfoxide
4: 1.) NaH / 1.) DMSO
5: NaBH4 / methanol / -40 °C
6: 65percent aq. acetic acid / 2 h / 50 °C
7: 54 percent / NaOH / methanol; H2O
With
pyridine; sodium hydroxide; sodium tetrahydroborate; t-butoxide; sulfur trioxide; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide;
DOI:10.1248/cpb.38.1769
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMSO
2: NaBH4 / methanol / -40 °C
3: 65percent aq. acetic acid / 2 h / 50 °C
4: 54 percent / NaOH / methanol; H2O
With
sodium hydroxide; sodium tetrahydroborate; sodium hydride; acetic acid;
In
methanol; water;
DOI:10.1248/cpb.38.1769