1-Benzyl-4-(4-fluoro-benzyl)-piperidin-4-ol

Base Information

Chemical Name:1-Benzyl-4-(4-fluoro-benzyl)-piperidin-4-ol
CAS No.:193357-11-8
Molecular Formula:C19H22FNO
Molecular Weight:299.388
Hs Code.:
DSSTox Substance ID:DTXSID40445517
Wikidata:Q82263957
Mol file:193357-11-8.mol

Synonyms:1-benzyl-4-(4-fluoro-benzyl)-piperidin-4-ol;193357-11-8;SCHEMBL5399810;DTXSID40445517;SPXWVGAGMKJNME-UHFFFAOYSA-N;1-benzyl-4-(4-fluorobenzyl)-4-hydroxypiperidine

Suppliers and Price of 1-Benzyl-4-(4-fluoro-benzyl)-piperidin-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 1-Benzyl-4-(4-fluoro-benzyl)-piperidin-4-ol

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:299.16854249
Heavy Atom Count:22
Complexity:326

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1(CC2=CC=C(C=C2)F)O)CC3=CC=CC=C3

Technology Process of 1-Benzyl-4-(4-fluoro-benzyl)-piperidin-4-ol

There total 1 articles about 1-Benzyl-4-(4-fluoro-benzyl)-piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 193357-11-8
1-benzyl-4-(4-fluorobenzyl)-4-hydroxypiperidine

Guidance literature:: With magnesium; ethylene dibromide; Yield given; Multistep reaction; 1.) THF, RT, 30 min, 2.) THF, from -40 deg C to RT, overnight;
DOI:10.1021/jm990148x

Reference yield: 77.0%

: 193357-11-8
1-benzyl-4-(4-fluorobenzyl)-4-hydroxypiperidine

: 193355-56-5
4-(4-fluorobenzyl)-4-hydroxypiperidine

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm990148x

Reference yield:

: 193357-11-8
1-benzyl-4-(4-fluorobenzyl)-4-hydroxypiperidine

: 231947-14-1
4-(4-fluorobenzyl)-1-but-3-ynyl-4-hydroxypiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / H₂, AcOH / 10 percent Pd/C / ethanol

2: NaHCO₃ / dimethylformamide / 80 °C

With hydrogen; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm990148x