4-(4-ETHYL-BENZYL)-PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-(4-ETHYL-BENZYL)-PIPERIDINE HYDROCHLORIDE
• CAS No.: 193357-73-2
• Molecular Formula: C14H21N.ClH
• Molecular Weight: 239.78400
• Mol file: 193357-73-2.mol

Synonyms:

Chemical Property of 4-(4-ETHYL-BENZYL)-PIPERIDINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000477mmHg at 25°C
• Boiling Point: 314.1oC at 760 mmHg
• Flash Point: 146.7oC
• PSA: 12.03000
• LogP: 3.92190

Purity/Quality:

97% ^*data from raw suppliers

4-(4-ETHYL-BENZYL)-PIPERIDINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-ETHYL-BENZYL)-PIPERIDINE HYDROCHLORIDE

There total 5 articles about 4-(4-ETHYL-BENZYL)-PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-4-(4-ethyl-benzyl)-piperidine; hydrochloride → 4-(4-ethylbenzyl)piperidine hydrochloride (193357-73-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; for 4h; under 2585.74 Torr;

DOI:10.1021/jo9824697

Reference yield:

4-ethylbenzyl bromide (57825-30-6) → 4-(4-ethylbenzyl)piperidine hydrochloride (193357-73-2)

Guidance literature:

With triphenylphosphine;

Reference yield:

4-ethylbenzyl bromide (57825-30-6) → 4-(4-ethylbenzyl)piperidine hydrochloride (193357-73-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 85 percent / diethyl ether / 20 °C

2.1: NaH; DMSO / 20 - 80 °C

3.1: hydrogen / PtO₂ / methanol / 4 h / 1551.44 Torr

3.2: HCl / methanol / 0.17 h

4.1: hydrogen / 10 percent Pd/C / ethanol; H₂O / 4 h / 2585.74 Torr

With hydrogen; sodium hydride; dimethyl sulfoxide; platinum(IV) oxide; palladium on activated charcoal; In methanol; diethyl ether; ethanol; water; 1.1: Alkylation / 2.1: Addition / 3.1: Hydrogenation / 3.2: Addition / 4.1: Hydrogenolysis;

DOI:10.1021/jo9824697

upstream raw materials:

4-ethylbenzyl bromide

1-benzyl-4-(4-ethyl-benzylidene)-piperidine

Refernces

• 1、 Zhou, Zhang-Lin,Keana, John F. W.. "A Practical Synthesis of 4-(Substituted-benzyl)piperidines and (±)-3-(Substituted-benzyl)pyrrolidines via a Wittig Reaction". . p. 3763 - 3766. Retrieved 2007/10/03.