L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-[4-[(2S)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-3-methoxy-3-oxopropyl]phenoxy]-O-(phenylmethyl)-, phenylmethyl ester

Base Information

Chemical Name:L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-[4-[(2S)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-3-methoxy-3-oxopropyl]phenoxy]-O-(phenylmethyl)-, phenylmethyl ester
CAS No.:193410-66-1
Molecular Formula:C43H50N2O10
Molecular Weight:754.877
Hs Code.:

L-Tyrosine,
N-[(1,1-dimethylethoxy)carbonyl]-3-[4-[(2S)-2-[[(1,1-dimethylethoxy)carb
onyl]amino]-3-methoxy-3-oxopropyl]phenoxy]-O-(phenylmethyl)-,
phenylmethyl ester

Synonyms:

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Chemical Property of L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-[4-[(2S)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-3-methoxy-3-oxopropyl]phenoxy]-O-(phenylmethyl)-, phenylmethyl ester

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Technology Process of L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-[4-[(2S)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-3-methoxy-3-oxopropyl]phenoxy]-O-(phenylmethyl)-, phenylmethyl ester

There total 13 articles about L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-[4-[(2S)-2-[[(1,1-dimethylethoxy)carb onyl]amino]-3-methoxy-3-oxopropyl]phenoxy]-O-(phenylmethyl)-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 224824-22-0
(S)-(4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenyl)boronic acid

: 224824-21-9
N-(tert-butyloxycarbonyl)-3-(3-hydroxy-4-benzyloxyphenyl)-L-alanine benzyl ester

: 193410-66-1
methyl N-[(1,1-dimethylethoxy)carbonyl]-O-[S]-[5-({[2-(1,1-dimethylethoxy)carbonyl]amino}-2-[(phenylmethoxy)carbonyl]ethyl)-2-(phenylmethoxy)phenyl]-L-tyrosinate

Guidance literature:: With copper diacetate; 4 Angstroem MS; In pyridine;
DOI:10.1021/jo9902751

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 193410-66-1
methyl N-[(1,1-dimethylethoxy)carbonyl]-O-[S]-[5-({[2-(1,1-dimethylethoxy)carbonyl]amino}-2-[(phenylmethoxy)carbonyl]ethyl)-2-(phenylmethoxy)phenyl]-L-tyrosinate

Guidance literature:: Multi-step reaction with 6 steps

2: NaOH / H₂O

3: K₂CO₃

4: 1.) H₂O₂, (PhSe)2, 2.) NH₃ / 2.) MeOH

5: 76 percent / NaHCO₃ / 2-methyl-butane

6: 71 percent / Cu(OAc)2, 4 Angstroem MS / pyridine

With sodium hydroxide; copper diacetate; 4 Angstroem MS; diphenyl diselenide; ammonia; dihydrogen peroxide; sodium hydrogencarbonate; potassium carbonate; In pyridine; methylbutane; water;
DOI:10.1021/jo9902751

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 193410-66-1
methyl N-[(1,1-dimethylethoxy)carbonyl]-O-[S]-[5-({[2-(1,1-dimethylethoxy)carbonyl]amino}-2-[(phenylmethoxy)carbonyl]ethyl)-2-(phenylmethoxy)phenyl]-L-tyrosinate

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / H₂O

2: K₂CO₃

3: 1.) H₂O₂, (PhSe)2, 2.) NH₃ / 2.) MeOH

4: 76 percent / NaHCO₃ / 2-methyl-butane

5: 71 percent / Cu(OAc)2, 4 Angstroem MS / pyridine

With sodium hydroxide; copper diacetate; 4 Angstroem MS; diphenyl diselenide; ammonia; dihydrogen peroxide; sodium hydrogencarbonate; potassium carbonate; In pyridine; methylbutane; water;
DOI:10.1021/jo9902751